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The association between amniotic fluid-derived inflammatory mediators and the risk of retinopathy of prematurity

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Author(s)
Jang, Ji HyeKim, Jae-GonLee, Yu HyunBae, Jin GonPark, Jae Hyun
Keimyung Author(s)
Jang, Ji HyeLee, You HyunBae, Jin GonPark, Jae Hyun
Department
Dept. of Ophthalmology (안과학)
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Pediatrics (소아청소년학)
Journal Title
Medicine (Baltimore)
Issued Date
2022
Volume
101
Issue
27
Keyword
amniotic fluidcesarean deliveryinflammatory mediatorsretinopathy of prematuritymatrix metalloproteinase
Abstract
Prenatal and perinatal infections and inflammation appear to associated with the development of retinopathy of prematurity (ROP). In this study, we evaluated whether inflammatory mediators in amniotic fluid (AF) retrieved during cesarean delivery influence the development of ROP in very low birth weight (VLBW) infants.

This retrospective study included 16 and 32 VLBW infants who did and did not develop any stage of ROP, respectively. Each infant with ROP was matched with 2 infants without ROP based on days of ventilation care, gestational age, and birth weight. AF was obtained during cesarean delivery, and the levels of intra-amniotic inflammatory mediators such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, matrix metalloproteinase (MMP)-2, MMP-8, MMP-9, and tumor necrosis factor (TNF)-α were measured using a Human Magnetic Luminex assay (R&D Systems, Minneapolis, MN). The differences in the levels of inflammatory mediators according to the presence or absence of ROP were compared.

In patients who developed ROP, the level of MMP-2 in the AF was significantly increased (P = .011), whereas the levels of IL-10 and TNF-α were significantly decreased (P = .028 and .046, respectively) compared with those in infants who did not develop ROP. The levels of the other mediators were not significantly different between the 2 groups. Multivariate regression analysis showed that MMP-2 was a risk factor for the development of ROP (odds ratio, 2.445; 95% confidence interval, 1.170-5.106; P = .017).

The concentration of MMP-2 in AF is an independent factor in the development of ROP. Further studies are needed to determine whether the levels of inflammatory mediators in AF affect the ROP severity.
Keimyung Author(s)(Kor)
장지혜
이유현
배진곤
박재현
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1536-5964
Source
https://journals.lww.com/md-journal/Fulltext/2022/07080/The_association_between_amniotic_fluid_derived.35.aspx
DOI
10.1097/MD.0000000000029368
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44398
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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