계명대학교 의학도서관 Repository

Genetic variants of interferon lambda-related genes and chronic kidney disease susceptibility in the Korean population

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Author(s)
Jin Ho KwakJin Hyuk PaekGyeong Im YuSeungyeup HanWoo Yeong ParkYaerim KimDong Hoon ShinKyubok Jin
Keimyung Author(s)
Paek, Jin HyukHan, Seung YeupPark, Woo YoungKim, Yae RimShin, Dong HoonJin, Kyu Bok
Department
Dept. of Internal Medicine (내과학)
Dept. of Preventive Medicine (예방의학)
Journal Title
Kidney Res Clin Pract
Issued Date
2022
Volume
41
Issue
4
Keyword
Chronic renal insufficiencyDNA replicationInterferon type IIISingle nucleotide polymorphism
Abstract
Background:
Chronic kidney disease (CKD) is a common condition leading to renal dysfunction and is closely related to increased cardiovascular and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. This research examines the interrelationship between candidate genes polymorphisms of interferon lambda (IFNL) induction, its signaling pathway, and CKD.

Methods:
Seventy-five patients with advanced CKD and 312 healthy subjects (as controls) participated in this research. A replication set composed of 172 patients with advanced CKD and 365 controls was used for additional analysis. The genotype of single nucleotide polymorphisms (SNPs) was determined by the Axiom Genome-Wide Human Assay and SNaPshot assay.

Results:
The SNP of IFNL3 was significantly associated with CKD in the codominant (p = 0.02) and dominant models (p = 0.02). In addition, the SNPs of IFNL2 were significantly associated with CKD in the dominant model (p = 0.03), and the SNP of interferon alpha receptor 2 (IFNAR2) was significantly associated with CKD in the log-additive model (p = 0.03). Concerning rs148543092, in the IFNL3 gene, a significant association was observed after pooling the original and replication sets.

Conclusion:
These results indicate that SNPs in the IFNL induction and signal pathway may be associated with CKD risk in the Korean population. Finally, our results also show that the IFNL3 gene variant may be associated with CKD risk.
Keimyung Author(s)(Kor)
백진혁
한승엽
박우영
김예림
신동훈
진규복
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2211-9140
Source
https://www.krcp-ksn.org/journal/view.php?doi=10.23876/j.krcp.21.075
DOI
10.23876/j.krcp.21.075
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44431
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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