계명대학교 의학도서관 Repository

Fibrotic Burden Determines Cardiovascular Risk among Subjects with Metabolic Dysfunction-Associated Fatty Liver Disease

Metadata Downloads
Author(s)
Eugene HanYong-ho LeeJae Seung LeeHye Won LeeBeom Kyung KimJun Yong ParkDo Young KimSang Hoon AhnByung-Wan LeeEun Seok KangBong-Soo ChaSeung Up Kim
Keimyung Author(s)
Han, Eu Gene
Department
Dept. of Internal Medicine (내과학)
Journal Title
Gut Liver
Issued Date
2022
Volume
16
Issue
5
Keyword
Metabolic dysfunction associated fatty liver diseaseNonalcoholic fatty liver diseaseCardiovascular diseaseLiver fibrosis
Abstract
Background/Aims:
Metabolic dysfunction associated fatty liver disease (MAFLD) has recently been introduced to compensate for the conventional concept of nonalcoholic fatty liver disease (NAFLD). We explored whether fibrotic burden determines the risk of atherosclerotic cardiovascular disease (ASCVD) among subjects with MAFLD.

Methods:
We recruited 9,444 participants from the Korea National Health and Nutrition Examination Survey (2008 to 2011). Liver fibrosis was identified using the fibrosis-4 (FIB-4) index and NAFLD fibrosis score. The 10-year ASCVD risk score (>10%) was used to determine a high probability ASCVD risk. For sensitivity analysis, propensity score matching was assessed to subjects with aged 40 to 75 years free from ASCVD.

Results:
The prevalence of MAFLD was 38.0% (n=3,592). The ASCVD risk scores stratified in quartile were positively correlated to MAFLD and FIB-4 defined-significant liver fibrosis (p for trend <0.001). Individuals with both MAFLD and FIB-4 defined-significant liver fibrosis had a greater chance of high probability ASCVD risk (odds ratio [OR]=2.40; p<0.001) than those without MAFLD. The impact of MAFLD on high probability ASCVD risk was greater than that of significant liver fibrosis (OR=4.72 for MAFLD vs OR=1.88 for FIB-4 defined-significant liver fibrosis; all p<0.001). Among participants with MAFLD, low muscle mass enhanced the risk of significant liver fibrosis (OR=1.56 to 2.43; p<0.001). When NAFLD fibrosis score was applied to define significant liver fibrosis, similar findings were observed.

Conclusions:
Individuals with MAFLD had a substantial ASCVD risk compared to those without MAFLD. Accompanying significant liver fibrosis further enhanced the risk of ASCVD among subjects with MAFLD.
Keimyung Author(s)(Kor)
한유진
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-1212
Source
https://www.gutnliver.org/journal/view.html?doi=10.5009/gnl210290
DOI
10.5009/gnl210290
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44433
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.