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The Pattern of Care for Brain Metastasis from Breast Cancer over the Past 10 Years in Korea: A Multicenter Retrospective Study (KROG 16-12)

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Author(s)
Jae Sik KimKyubo KimWonguen JungKyung Hwan ShinSeock-Ah ImHee-Jun KimYong Bae KimJee Suk ChangJee Hyun KimDoo Ho ChoiYeon Hee ParkDae Yong KimTae Hyun KimByung Ock ChoiSea-Won LeeSuzy KimJeanny KwonKi Mun KangWoong-Ki ChungKyung Su KimJi Ho NamWon Sup YoonJin Hee KimJihye ChaYoon Kyeong OhIn Ah Kim
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Cancer Res Treat
Issued Date
2022
Volume
54
Issue
4
Keyword
Brain metastasisBreast neoplasmsOverall survivalPattern of care study
Abstract
Purpose:
We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea.

Materials and Methods:
We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed (group I [2005–2008], 98 patients; group II [2009–2011], 200 patients; and group III [2012–2014], 302 patients).

Results:
Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years; p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p=0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance.

Conclusion:
The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2021.1083
DOI
10.4143/crt.2021.1083
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44454
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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