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Clinical Usefulness of Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging in Children With Focal Epilepsy

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Author(s)
Yun Jeong LeeHyunwoo BaeJun Chul ByunSoonhak KwonSung Suk OhSaeyoon Kim
Keimyung Author(s)
Byun, Jun Chul
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
J Clin Neurol
Issued Date
2022
Volume
18
Issue
5
Keyword
electroencephalographyfunctional magnetic resonance imagingchildfocal epilepsy
Abstract
Background and Purpose:
The current study analyzed the interictal epileptiform discharge (IED)-related hemodynamic response and aimed to determine the clinical usefulness of simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) in defining the epileptogenic zone (EZ) in children with focal epilepsy.

Methods:
Patients with focal epilepsy showing IEDs on conventional EEG were evaluated using EEG-fMRI. Statistical analyses were performed using the times of spike as events modeled with multiple hemodynamic response functions. The area showing the most significant t-value for blood-oxygen-level-dependent (BOLD) changes was compared with the presumed EZ. Moreover, BOLD responses between -9 and +9 s around the spike times were analyzed to track the hemodynamic response patterns over time.

Results:
Half (n=13) of 26 EEG-fMRI investigations of 19 patients were successful. Two patients showed 2 different types of spikes, resulting in 15 analyses. The maximum BOLD response was concordant with the EZ in 11 (73.3%) of the 15 analyses. In 10 (66.7%) analyses, the BOLD response localized the EZs more specifically. Focal BOLD responses in the EZs occurred before IEDs in 11 analyses and were often widespread after IEDs. Hemodynamic response patterns were consistent in the same epilepsy syndrome or when repeating the investigation in the same patients.

Conclusions:
EEG-fMRI can provide additional information for localizing the EZ in children with focal epilepsy, and also reveal the pathogenesis of pediatric epilepsy by evaluating the patterns in the hemodynamic response across time windows of IEDs.
Keimyung Author(s)(Kor)
변준철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-5013
Source
https://thejcn.com/DOIx.php?id=10.3988/jcn.2022.18.5.535
DOI
10.3988/jcn.2022.18.5.535
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44464
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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