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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea

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Author(s)
Youseung ChungEun Jin KimHee-Sung KimKyung-Hwa ParkJi Hyeon BaekJungok KimJi Yeon LeeChang-Seop LeeSeungjin LimShin-Woo KimEu Suk KimHye Jin ShiShin Hee HongJae-Bum JunKyung-Wook HongJae-Phil ChoiJinyeong KimKyung Sook YangYoung Kyung Yoon
Keimyung Author(s)
Lee, Ji Yeon
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Korean Med Sci
Issued Date
2022
Volume
37
Issue
41
Keyword
Severe Acute Respiratory Syndrome Coronavirus 2Coronavirus Disease 2019PregnancyNeonate
Abstract
Background:
This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.

Methods:
This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.

Results:
A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04–1.15) and parity (OR, 1.703, 95% CI, 1.13–2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.

Conclusion:
At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
Keimyung Author(s)(Kor)
이지연
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1598-6357
Source
https://jkms.org/DOIx.php?id=10.3346/jkms.2022.37.e297
DOI
10.3346/jkms.2022.37.e297
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44468
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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