계명대학교 의학도서관 Repository

심리적 스트레스와 세포노화 지표로서의 텔로미어 길이의 연관성: 체계적 문헌고찰

Metadata Downloads
Author(s)
Seolbin HanSangeun JunNahyun Kim
Keimyung Author(s)
Jun, Sang EunKim, Na Hyun
Department
Dept. of Nursing (간호학)
Journal Title
KOREAN J ADULT NURS
Issued Date
2022
Volume
34
Issue
5
Keyword
심리적 스트레스텔로미어텔로미어 단축체계적 문헌고찰StresspsychologicalTelomereTelomere shorteningSystematic review
Abstract
Purpose:
This study aimed to synthesize evidence for the association of psychological stress with Telomere Length (TL)-a potential biomarker of cellular aging.

Methods:
A systematic literature search was conducted to identify eligible studies in the Cochrane Library, PubMed, Embase, and CINHAL. In this review, we included all papers published since the initiative's inception and summarized results as of March 2022. Studies that investigated subjective stress using questionnaires and objective stress using biomarkers of adults (aged≥18 years) were included. Ultimately, 20 studies met our selection criteria. The risk of bias was assessed using the Newcastle-Ottawa Scale.

Results:
Fifteen of the twenty studies (75.0%) reported that individuals with higher psychological stress levels had shorter TL. Eleven of sixteen studies (68.8%) measuring subjective stress and five of eight studies (62.5%) measuring objective stress showed significant associations of psychological stress with TL. However, five studies reported no association between psychological stress and TL shortening. Although the heterogeneous studies limited the ability to draw clear conclusions, it is suggested that psychological stress might accelerate the erosion of telomere ends.

Conclusion:
Our findings indicate that TL could be a useful emerging biomarker for measuring stress-related health outcomes in nursing. Further large-scale longitudinal studies using TL as a genetic biomarker with multidimensional stress measurements are needed to investigate the association between psychological stress and cellular senescence.
Alternative Title
Association of Psychological Stress with Telomere Length as a Biomarker of Cellular Aging: A Systematic Review
Keimyung Author(s)(Kor)
전상은
김나현
Publisher
College of Nursing (간호대학)
Type
Article
ISSN
2288-338x
Source
https://kjan.or.kr/DOIx.php?id=10.7475/kjan.2022.34.5.450
DOI
10.7475/kjan.2022.34.5.450
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44489
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.