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Characteristics and outcomes of heart transplant recipients with a pretransplant history of malignancy

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Author(s)
Jong-Chan YounDarae KimKyung An KimJin-Jin KimIn-Cheol KimHye Sun LeeJin-Oh ChoiEun-Seok JeonKeith NishiharaEvan P. KransdorfDavid H. ChangMichelle M. KittlesonJignesh K. PatelDanny RamzyFardad EsmailianJon A. Kobashigawa
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Am J Transplant
Issued Date
2022
Volume
22
Issue
12
Keyword
heart transplantposttransplant malignancypretransplant malignancyprognosisrecurrencesurvival
Abstract
We aimed to investigate the characteristics and outcomes of HTx recipients with a history of pretransplant malignancy (PTM). Among 1062 HTx recipients between 1997 and 2013, 73 (7.1%) patients had PTMs (77 cancer cases). We analyzed post-HTx outcome, recurrence of PTM, and development of de novo malignancies. Post-HTx outcome included overall survival, 10-year survival, 10-year freedom from cardiac allograft vasculopathy (CAV), non-fatal major adverse cardiac events (NF-MACE), any treated rejection (ATR), acute cellular rejection (ACR), and antibody-mediated rejection (AMR). Four most common PTMs were lymphoproliferative disorders (18.2%), prostate cancers (18.2%), non-melanoma skin cancers (18.2%), and breast cancers (13.0%). Median time from PTM and HTx was 9.0 years. During a median follow-up of 8.6 years after HTx, patients with PTM, compared to those without, showed significantly higher incidence of posttransplant malignancies (43.8% vs. 20.8%, p < .001) including 9.6% (n = 7) of PTM recurrences. However, patients with PTM, compared to those without, showed comparable overall survival, 10-year survival, 10-year freedom from CAV, NF-MACE, ATR, ACR, and AMR. Therefore, a history of PTM should not disqualify patients from HTx listing, while further research is necessary for early detection of posttransplant malignancies in these patients.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1600-6143
Source
https://onlinelibrary.wiley.com/doi/10.1111/ajt.17186
DOI
10.1111/ajt.17186
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44503
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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