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Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategies

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Author(s)
Prabhat ShresthaNikita KatilaSooyeun LeeJi Hae SeoJee-Heon JeongSimmyung Yook
Keimyung Author(s)
Seo, Ji Hye
Department
Dept. of Biochemistry (생화학)
Journal Title
Biomed Pharmacother
Issued Date
2022
Volume
154
Keyword
ExcitotoxicityMethamphetamineNeurotoxic diseaseNeurotoxicityOxidative stressTargeted therapy
Abstract
Methamphetamine (MA) is a extremely addictive psychostimulant drug with a significant abuse potential. Long-term MA exposure can induce neurotoxic effects through oxidative stress, mitochondrial functional impairment, endoplasmic reticulum stress, the activation of astrocytes and microglial cells, axonal transport barriers, autophagy, and apoptosis. However, the molecular and cellular mechanisms underlying MA-induced neurotoxicity remain unclear. MA abuse increases the chances of developing neurotoxic conditions such as Parkinson's disease (PD), Alzheimer's disease (AD) and other neurotoxic diseases. MA increases the risk of PD by increasing the expression of alpha-synuclein (ASYN). Furthermore, MA abuse is linked to high chances of developing AD and subsequent neurodegeneration due to biological variations in the brain region or genetic and epigenetic variations. To date, there is no Food and Drug Administration (FDA)-approved therapy for MA-induced neurotoxicity, although many studies are being conducted to develop effective therapeutic strategies. Most current studies are now focused on developing therapies to diminish the neurotoxic effects of MA, based on the underlying mechanism of neurotoxicity. This review article highlights current research on several therapeutic techniques targeting multiple pathways to reduce the neurotoxic effects of MA in the brain, as well as the putative mechanism of MA-induced neurotoxicity.
Keimyung Author(s)(Kor)
서지혜
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
0753-3322
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0753332222009805?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0753332222009805%3Fshowall%3Dtrue&referrer=https:%2F%2Fpubmed.ncbi.nlm.nih.gov%2F
DOI
10.1016/j.biopha.2022.113591
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44504
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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