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Long-term prognosis of curative endoscopic submucosal dissection for early colorectal cancer according to submucosal invasion: a multicenter cohort study

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Author(s)
Jongbeom ShinEun Ran KimHyun Joo JangDong Hoon BaekDong-Hoon YangBo-In LeeKwang Bum ChoJin Woong ChoSung-Ae JungSu Jin HongBong Min Ko
Keimyung Author(s)
Cho, Kwang Bum
Department
Dept. of Internal Medicine (내과학)
Journal Title
BMC Gastroenterol
Issued Date
2022
Volume
22
Issue
1
Keyword
Early colorectal cancerEndoscopic submucosal dissectionRecurrence free survival
Abstract
Background:
Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally required, and reports on the long-term prognosis of ESD are insufficient. This study aimed to investigate the long-term outcomes of ECC removal by ESD, including local recurrence and metastasis.

Methods:
This multicenter study was conducted retrospectively on 450 consecutive patients with ECC who were treated with ESD between November 2003 and December 2013. Clinical, pathological, and endoscopic data were collected to determine tumor depth, resection margin, lymphovascular invasion, and recurrence.

Results:
The median follow-up period was 53.8 (12-138 months). The en bloc resection rate was 85.3% (384) and in intramucosal cancer being 84.1% and in superficial submucosal invasion (SM1) cancer being 89.8% (p = 0.158). The curative resection rate was 76.0% (n = 342), and there was no statistical difference between the two groups (77.3% vs. 71.4%, p = 0.231). The overall recurrence free survival rate (RFS) was 98.7% (444/450). In patients with curative resection, there was no statistically significant difference in RFS according to invasion depth (intramucosal: 99.3% vs. SM1: 97.1%, p = 0.248).

Conclusions:
Patients with curatively resected ECC treated with ESD showed favorable long-term outcomes. Curatively resected SM1 cancer has a RFS similar to that of intramucosal cancer.
Keimyung Author(s)(Kor)
조광범
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1471-230X
Source
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-022-02499-0
DOI
10.1186/s12876-022-02499-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44508
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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