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Circular Noncoding RNA hsa_circ_0003570 as a Prognostic Biomarker for Hepatocellular Carcinoma

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Author(s)
Se Young JangGyeonghwa KimWon Young TakYoung Oh KweonYu Rim LeeYoung Seok HanJa Ryung HanJung Gil ParkMin Kyu KangHye Won LeeWon Kee LeeSoo Young ParkKeun Hur
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Genes (Basel)
Issued Date
2022
Volume
13
Issue
8
Keyword
biomarkercircular RNAepigeneticshepatocellular carcinomaprognosisprogressionsurvival
Abstract
Circular RNAs (circRNAs) are potential biomarkers owing to their stability, tissue specificity, and abundance. This study aimed to evaluate the clinical significance of hsa_circ_0003570 expression and to investigate its potential as a biomarker in hepatocellular carcinoma (HCC). We evaluated hsa_circ_0003570 expression in 121 HCC tissue samples, its association with clinicopathological characteristics, and overall and progression-free survival. Hsa_circ_0003570 expression was downregulated in HCC tissues. Low hsa_circ_0003570 expression was more common in tumors larger than 5 cm (odds ratio (OR), 6.369; 95% confidence interval (CI), 2.725-14.706; p < 0.001), vessel invasion (OR, 5.128; 95% CI, 2.288-11.494; p < 0.001); advanced tumor-node metastasis stage (III/IV; OR, 4.082; 95% CI, 1.866-8.929; p < 0.001); higher Barcelona Clinic Liver Cancer stage (B/C; OR, 3.215; 95% CI, 1.475-6.993; p = 0.003); and higher AFP (>200 ng/mL; OR, 2.475; 95% CI, 1.159-5.291; p = 0.018). High hsa_circ_0003570 expression was an independent prognostic factor for overall survival (hazard ratio (HR), 0.541; 95% confidence interval (CI), 0.327-0.894; p = 0.017) and progression-free survival (HR, 0.633; 95% CI, 0.402-0.997; p = 0.048). Hsa_circ_0003570 is a potential prognostic biomarker in patients with HCC, and further validation of hsa_circ_0003570 is needed.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2073-4425
Source
https://www.mdpi.com/2073-4425/13/8/1484
DOI
10.3390/genes13081484
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44535
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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