계명대학교 의학도서관 Repository

The Role of Serum CD26 in the Diagnosis of Gastric Cancer

Metadata Downloads
Author(s)
Ju Yup LeeMae-Ja Park
Keimyung Author(s)
Lee, Ju Yup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Int J Gen Med
Issued Date
2022
Volume
15
Keyword
CD26HER2biomarkergastric cancer
Abstract
Purpose:
The value of serum cluster of differentiation 26 (CD26) in gastric cancer remains unknown. We investigated serum CD26 as a non-invasive serological marker for the diagnosis of gastric cancer and its relationship with serum human epidermal growth factor receptor-2 (HER2) levels.

Patients and methods:
We enrolled 393 gastric cancer patients treated with endoscopic resection or surgery, and 90 healthy controls. HER2 positivity in tissue was evaluated by immunohistochemistry staining, and the serum CD26 and HER2 levels were measured using an enzyme-linked immunosorbent assay.

Results:
Serum CD26 levels were significantly lower in gastric cancer patients than in healthy controls (582.2 ± 254.3 vs 862.7 ± 410.6 ng/mL, P<0.001). Serum CD26 levels were significantly lower in advanced gastric cancer compared to early gastric cancer (642.2 ± 333.9 vs 503.4 ± 332.7 ng/mL, P<0.001), and tended to decrease with gastric cancer progression. To diagnose gastric cancer, the optimal cut-off value of serum CD26 was 762.7 ng/mL with 75.6% sensitivity and 64.4% specificity. Serum CD26 levels were weakly correlated with serum HER2 levels (rs=0.363, P<0.001). However, no difference in serum CD26 levels was observed between tissue HER2-negative and HER2-positive gastric cancer groups (586.2 ± 362.1 vs 579.6 ± 264.8 ng/mL, P=0.898).

Conclusion:
CD26 is a useful non-invasive serological marker for gastric cancer diagnosis; however, its levels do not correlate with HER2 status.
Keimyung Author(s)(Kor)
이주엽
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1178-7074
Source
https://www.dovepress.com/the-role-of-serum-cd26-in-the-diagnosis-of-gastric-cancer-peer-reviewed-fulltext-article-IJGM
DOI
10.2147/IJGM.S378620
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44541
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.