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Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation

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Author(s)
Kuk Hui SonWoong-Han KimJae Gun KwakChang-Hyu ChoiSeok In LeeUi Won KoHyoung Soo KimHaeyoung LeeEuy Suk ChungJae-Bum KimWoo Sung JangJae Seung JungJieon KimYoung Kyung YoonSeunghwan SongMinji SungMyung Hun JangYoung Sam KimIn-Seok JeongDo Wan KimTae Yun KimSoon Jin KimSu Wan KimJoonhwa HongHyungmi An
Keimyung Author(s)
Jang, Woo Sung
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
J Clin Med
Issued Date
2022
Volume
11
Issue
17
Keyword
COVID-19diabetesextracorporeal membranehyperglycemiahypoglycemia
Abstract
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) < 18.5 kg/m2. Glucose at admission >200 mg/dL and glucose levels before ventilator >200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO >200 mg/dL and minimal glucose levels during hospitalization <70 mg/dL were associated with in-hospital mortality. Multivariable Cox regression analysis showed that glucose >200 mg/dL before ECMO and minimal glucose <70 mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose >200 mg/dL before ECMO and minimal glucose level <70 mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.
Keimyung Author(s)(Kor)
장우성
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/11/17/5106
DOI
10.3390/jcm11175106
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44549
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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