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Nationwide Surveillance of Antifungal Resistance of Candida Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS

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Author(s)
Eun Jeong WonMin Ji ChoiSeok Hoon JeongDokyun KimKyeong Seob ShinJeong Hwan ShinYoung Ree KimHyun Soo KimYoung Ah KimYoung UhNamhee RyooJeong Su ParkKyoung Un ParkSeung A ByunGa Yeong LeeSoo Hyun KimJong Hee Shin
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
J Fungi (Basel)
Issued Date
2022
Volume
8
Issue
10
Keyword
Candida speciesGLASSantifungal surveillancecandidemia
Abstract
We incorporated nationwide Candida antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospitals during 2020-2021, based on GLASS early implementation protocol for the inclusion of Candida species. Candida species ranked fourth among 10,758 target blood pathogens and second among 4050 hospital-origin blood pathogens. Among 766 Candida blood isolates, 87.6% were of hospital origin, and 41.3% occurred in intensive care unit patients. Adults > 60 years of age accounted for 75.7% of cases. Based on species-specific clinical breakpoints, non-susceptibility to fluconazole, voriconazole, caspofungin, micafungin, and anidulafungin was found in 21.1% (154/729), 4.0% (24/596), 0.1% (1/741), 0.0% (0/741), and 0.1% (1/741) of the isolates, respectively. Fluconazole resistance was determined in 0% (0/348), 2.2% (3/135, 1 Erg11 mutant), 5.3% (7/133, 6 Pdr1 mutants), and 5.6% (6/108, 4 Erg11 and 1 Cdr1 mutants) of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis isolates, respectively. An echinocandin-resistant C. glabrata isolate harbored an F659Y mutation in Fks2p. The inclusion of Candida species in the Kor-GLASS system generated well-curated surveillance data and may encourage global Candida surveillance efforts using a harmonized GLASS system.
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2309-608X
Source
https://www.mdpi.com/2309-608X/8/10/996
DOI
10.3390/jof8100996
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44552
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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