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A study on changes in lung function, neutralizing antibodies, and symptoms of adult patients hospitalized with COVID-19

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Author(s)
Moon Seong Ba다Seong-Ho ChoiWon-Young KimMin-Chul KimEun-Jeong JooMi Suk LeeHyun Ah KimSook In JungYu Shi NaeBongyoung KimYaeji LimJin-Won Chung
Keimyung Author(s)
Kim, Hyun Ah
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean J Intern Med
Issued Date
2023
Volume
38
Issue
1
Keyword
AntibodiesCOVID-19Post-acute COVID-19 syndromeRadiography, thoracicRespiratory function tests
Abstract
Background/aims:
To identify changes in symptoms and pulmonary sequelae in patients with coronavirus disease 2019 (COVID-19).

Methods:
Patients with COVID-19 hospitalized at seven university hospitals in Korea between February 2020 and February 2021 were enrolled, provided they had ≥ 1 outpatient follow-up visit. Between January 11 and March 9, 2021 (study period), residual symptom investigations, chest computed tomography (CT) scans, pulmonary function tests (PFT), and neutralizing antibody tests (NAb) were performed at the outpatient visit (cross-sectional design). Additionally, data from patients who already had follow-up outpatient visits before the study period were collected retrospectively.

Results:
Investigation of residual symptoms, chest CT scans, PFT, and NAb were performed in 84, 35, 31, and 27 patients, respectively. After 6 months, chest discomfort and dyspnea persisted in 26.7% (4/15) and 33.3% (5/15) patients, respectively, and 40.0% (6/15) and 26.7% (4/15) patients experienced financial loss and emotional distress, respectively. When the ratio of later CT score to previous ones was calculated for each patient between three different time intervals (1-14, 15-60, and 61-365 days), the median values were 0.65 (the second interval to the first), 0.39 (the third to the second), and 0.20 (the third to the first), indicating that CT score decreases with time. In the high-severity group, the ratio was lower than in the low-severity group.

Conclusion:
In COVID-19 survivors, chest CT score recovers over time, but recovery is slower in severely ill patients. Subjects complained of various ongoing symptoms and socioeconomic problems for several months after recovery.
Keimyung Author(s)(Kor)
김현아
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-6648
Source
https://www.kjim.org/journal/view.php?doi=10.3904/kjim.2022.050
DOI
10.3904/kjim.2022.050
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44562
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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