계명대학교 의학도서관 Repository

A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea

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Author(s)
Jae Hui KimMin SagongSe Joon WooYu Cheol KimHeeyoon ChoYoung Hoon LeeIksoo ByonYoung Joon JoHee Seung ChinYoukyung LeeJae Eun ChaeSe Woong Kang
Keimyung Author(s)
Kim, Yu Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Sci Rep
Issued Date
2022
Volume
12
Issue
1
Abstract
To evaluate the real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) in Korea, focusing on retinal fluid resolution. This multi-institutional retrospective chart review study, analyzed medical records of patients with nAMD (age ≥ 50 years) who received their first anti-vascular endothelial growth factor (VEGF) treatment in ophthalmology clinics across South Korea between January 2017 and March 2019. The primary endpoint was the proportion of patients with retinal fluid after 12 months of anti-VEGF treatment. The association between fluid-free period and VA gains was also evaluated. A total of 600 patients were enrolled. At baseline, 97.16% of patients had retinal fluid; after 12 months of anti-VEGF treatment, 58.10% of patients had persistent retinal fluid. VA improvements were relatively better in patients with absence of retinal fluid compared with presence of retinal fluid (+ 12.29 letters vs. + 6.45 letters at month 12; P < .0001). Longer duration of absence of retinal fluid over first 12 months correlated with better VA gains at month 12 (P < .01). More than half of the study patients with nAMD had retinal fluid even after 12 months of treatment with their current anti-VEGF. Presence of retinal fluid was associated with relatively worse VA outcomes.
Keimyung Author(s)(Kor)
김유철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-022-18158-z
DOI
10.1038/s41598-022-18158-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44586
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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