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Impact of Renal Function on Short-Term Outcome After Reperfusion Therapy in Patients With Ischemic Stroke

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Author(s)
Hyungjong ParkYoung Dae KimHyo Suk NamJoonsang YooSung-Il SohnJeong-Ho HongByung Moon KimDong Joon KimOh Young BangWoo-Keun SeoJong-Won ChungKyung-Yul LeeYo Han JungHye Sun LeeSeong Hwan AhnDong Hoon ShinHye-Yeon ChoiHan-Jin ChoJang-Hyun BaekGyu Sik KimKwon-Duk SeoSeo Hyun KimTae-Jin SongJinkwon KimSang Won HanJoong Hyun ParkSuk Ik LeeJoon Nyung HeoHyung Woo LeeIl Hyung LeeMinyoul BaikJi Hoe Heo
Keimyung Author(s)
Park, Hyung JongSohn, Sung IlHong, Jeong Ho
Department
Dept. of Neurology (신경과학)
Journal Title
Stroke
Issued Date
2022
Volume
53
Issue
12
Keyword
glomerular filtration rateischemic strokemortalityreperfusionthrombectomy
Abstract
Background:
A high and low estimated glomerular filtration rate (eGFR) could affect outcomes after reperfusion therapy for ischemic stroke. This study aimed to determine whether renal function based on eGFR affects mortality risk in patients with ischemic stroke within 6 months following reperfusion therapy.

Methods:
This prospective registry-based cohort study included 2266 patients who received reperfusion therapy between January 2000 and September 2019 and were registered in the SECRET (Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy) study or the Yonsei Stroke Cohort. A high and low eGFR were based on the Chronic Kidney Disease Epidemiology Collaboration equation and defined, respectively, as the 5th and 95th percentiles of age- and sex-specific eGFR. Occurrence of death within 6 months was compared among the groups according to their eGFR such as low, normal, or high eGFR.

Results:
Of the 2266 patients, 2051 (90.5%) had a normal eGFR, 110 (4.9%) a low eGFR, and 105 (4.6%) a high eGFR. Patients with high eGFR were younger or less likely to have hypertension, diabetes, or atrial fibrillation than the other groups. Active cancer was more prevalent in the high-eGFR group. During the 6-month follow-up, there were 24 deaths (22.9%) in the high-eGFR group, 37 (33.6%) in the low-eGFR group, and 237 (11.6%) in the normal-eGFR group. After adjusting for variables with P<0.10 in the univariable analysis, 6-month mortality was independently associated with high eGFR (hazard ratio, 2.22 [95% CI, 1.36-3.62]; P=0.001) and low eGFR (HR, 2.29 [95% CI, 1.41-3.72]; P=0.001). These associations persisted regardless of treatment modality or various baseline characteristics.

Conclusions:
High eGFR as well as low eGFR were independently associated with 6-month mortality after reperfusion therapy. Kidney function could be considered a prognostic factor in patients with ischemic stroke after reperfusion therapy.
Keimyung Author(s)(Kor)
박형종
손성일
홍정호
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1524-4628
Source
https://www.ahajournals.org/doi/10.1161/STROKEAHA.122.039129
DOI
10.1161/STROKEAHA.122.039129
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44587
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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