계명대학교 의학도서관 Repository

Characteristics and Effect of Rivaroxaban on Venous Thromboembolism in Korean Patients Compared to Western Population: A Subgroup Analysis from XALIA(-LEA) Study

Metadata Downloads
Author(s)
Seung-Kee MinJi-Sun KimJang Yong KimUi Jun ParkTaehoon LeeJin Mo KangSun Cheol ParkWon-Il ChoiKi-Hyuk ParkMartin Gebel
Keimyung Author(s)
Park, Ui Jun
Department
Dept. of Surgery (외과학)
Journal Title
Vasc Spec Int
Issued Date
2022
Volume
38
Issue
4
Keyword
AnticoagulantsEthnicityRivaroxabanSouth KoreaVenous thromboembolism
Abstract
Purpose:
This study aimed to compare the characteristics of venous thromboembolic disease (VTE) in Korean to Caucasian population.

Materials and methods:
XALIA-LEA and XALIA were phase IV non-interventional prospective studies with identical designs that investigated the effect of rivaroxaban versus standard anticoagulation for VTE. Koreans accounted for the largest proportion of the overall enrolled population of XALIA-LEA. However, in the XALIA study, most patients were Caucasian. Therefore, Korean data from XALIA-LEA and Caucasian data from XALIA were used in this study. This study compared the clinical characteristics and primary outcomes of the XALIA program, including major bleeding, recurrent VTE, and all-cause mortality.

Results:
The Korean population was older, was less obese, and had more active cancer at baseline than the Caucasian population. Provoked VTE was more common in the Korean population. Interestingly, Koreans showed less accompanying thrombophilia than Caucasians, and factor V Leiden mutations were not detected. Korean analyses comparing the effects of rivaroxaban and standard anticoagulation with primary outcomes showed a lower incidence of major bleeding, recurrent VTE, and all-cause mortality with rivaroxaban. Similar results were obtained in the propensity score matching analysis.

Conclusion:
Characteristic differences were found between Korean and Caucasian VTE patients. Despite these ethnic differences, the effectiveness and safety of rivaroxaban therapy in these patients were consistent.
Keimyung Author(s)(Kor)
박의준
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2288-7989
Source
https://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.220039
DOI
10.5758/vsi.220039
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44666
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.