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Optimal Duration of Dual Antiplatelet Therapy after Stent- Assisted Coil Embolization of Unruptured Intracranial Aneurysms : A Prospective Randomized Multicenter Trial

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Author(s)
Seung Pil BanO-Ki KwonYoung Deok KimBum-Tae KimJae Sang OhKang Min KimChang Hyeun KimChang-Hyun KimJai Ho ChoiYoung Woo KimYong Cheol LimHyoung Soo ByounSukh Que ParkJoonho ChungKeun Young ParkJung Cheol ParkHyon-Jo Kwon
Keimyung Author(s)
Kim, Chang Hyun
Department
Dept. of Neurosurgery (신경외과학)
Journal Title
대한신경외과학회지
Issued Date
2022
Volume
65
Issue
6
Keyword
Dual anti-platelet therapyEndovascular proceduresIntracranial aneurysmStentsThromboembolism
Abstract
Objective:
Stent-assisted coil embolization (SAC) has been increasingly used to treat various types of intracranial aneurysms. Delayed thromboembolic complications are major concerns regarding this procedure, so dual antiplatelet therapy with aspirin and clopidogrel is needed. However, clinicians vary the duration of dual antiplatelet therapy after SAC, and no randomized study has been performed. This study aims to compare the safety and efficacy of long-term (12 months) dual antiplatelet therapy and short-term dual antiplatelet therapy (6 months) after SAC for patients with unruptured intracranial aneurysms (UIAs).

Methods:
This is a prospective, randomized and multicenter trial to investigate the optimal duration of dual antiplatelet therapy after SAC in patients with UIAs. Subjects will receive dual antiplatelet therapy for 6 months (short-term group) or 12 months (long-term group) after SAC. The primary endpoint is the assessment of thromboembolic complications between 1 and 18 months after SAC. We will enroll 528 subjects (264 subjects in each group) and perform 1 : 1 randomization. This study will involve 14 top-performing, high-volume Korean institutions specializing in coil embolization.

Results:
The trial will begin enrollment in 2022, and clinical data will be available after enrollment and follow-up.

Conclusion:
This article describes that the aim of this prospective randomized multicenter trial is to compare the effect of short-term (6 months) and long-term (12 months) dual antiplatelet therapy on UIAs in patients undergoing SAC, and to find the optimal duration.
Keimyung Author(s)(Kor)
김창현
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1598-7876
Source
https://www.jkns.or.kr/journal/view.php?doi=10.3340/jkns.2022.0082
DOI
10.3340/jkns.2022.0082
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44668
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
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