계명대학교 의학도서관 Repository

Associations of body mass index and weight change with circulating levels of high-sensitivity C-reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors

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Author(s)
Hyun Jeong ChoSihan SongZisun KimHyun Jo YounJihyoung ChoJun Won MinYoo Seok KimSang-Woon ChoiJung Eun Lee
Keimyung Author(s)
Cho, Ji Hyoung
Department
Dept. of Surgery (외과학)
Journal Title
Asia Pac J Clin Oncol
Issued Date
2023
Volume
19
Issue
1
Keyword
body mass indexbreast cancer survivorsinflammatory markersKoreaweight change
Abstract
Aim:
This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea.

Methods:
A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. The plasma levels of inflammatory markers were measured, including high-sensitivity C-reactive protein, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and adiponectin. A summary z-score was calculated by summing up the z-scores of each biomarker. The least-square means and 95% confidence intervals (CIs) were calculated using a generalized linear model and odds ratios (ORs) and 95% CIs for the elevated levels of inflammatory markers with a multivariate logistic regression model.

Results:
Participants with a BMI ≥27.5 kg/m2 at the study enrollment and at diagnosis were significantly associated with elevated summary z-scores compared to those with a BMI < 23 kg/m2; the ORs (95% CIs) were 5.42 (2.15–13.71) for current BMI and 3.66 (1.68–7.98) for BMI at diagnosis, respectively. Additionally, a weight loss > 5% since diagnosis was associated with a lower prevalence of high summary z-scores; the OR (95% CI) was .20 (.08–.52) compared to a stable weight.

Conclusions:
A high BMI at diagnosis and current BMI with a greater degree were associated with unfavorable levels of inflammatory markers among breast cancer survivors. Additionally, weight loss since diagnosis was inversely associated with these markers.
Keimyung Author(s)(Kor)
조지형
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1743-7563
Source
https://onlinelibrary.wiley.com/doi/10.1111/ajco.13779
DOI
10.1111/ajco.13779
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44700
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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