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Epidemiologic and Clinical Outcomes of Pediatric Renal Tumors in Korea: A Retrospective Analysis of The Korean Pediatric Hematology and Oncology Group (KPHOG) Data

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Author(s)
Kyung-Nam KohJung Woo HanHyoung Soo ChoiHyoung Jin KangJi Won LeeKeon Hee YooKi Woong SungHong Hoe KooKyung Taek HongJung Yoon ChoiSung Han KangHyery KimHo Joon ImSeung Min HahnChuhl Joo LyuHee-Jo BaekHoon KookKyung Mi ParkEu Jeen YangYoung Tak LimSeongkoo KimJae Wook LeeNack-Gyun ChungBin ChoMeerim ParkHyeon Jin ParkByung-Kiu ParkJun Ah LeeJun Eun ParkSoon Ki KimJi Yoon KimHyo Sun KimYoungeun MaKyung Duk ParkSang Kyu ParkEun Sil ParkYe Jee ShimEun Sun YooKyung Ha RyuJae Won YooYeon Jung LimHoi Soo YoonMee Jeong LeeJae Min LeeIn-Sang JeonHye Lim JungHee Won ChuehSeunghyun Won
Keimyung Author(s)
Shim, Ye Jee
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Cancer Res Treat
Issued Date
2023
Volume
55
Issue
1
Keyword
ChildEpidemiologyRenal tumors
Abstract
Purpose:
Renal tumors account for approximately 7% of all childhood cancers. These include Wilms tumor (WT), clear cell sarcoma of the kidney (CCSK), malignant rhabdoid tumor of the kidney (MRTK), renal cell carcinoma (RCC), congenital mesoblastic nephroma (CMN) and other rare tumors. We investigated the epidemiology of pediatric renal tumors in Korea.

Materials and methods:
From January 2001 to December 2015, data of pediatric patients (0-18 years) newly-diagnosed with renal tumors at 26 hospitals were retrospectively analyzed.

Results:
Among 439 patients (male, 240), the most common tumor was WT (n=342, 77.9%), followed by RCC (n=36, 8.2%), CCSK (n=24, 5.5%), MRTK (n=16, 3.6%), CMN (n=12, 2.7%), and others (n=9, 2.1%). Median age at diagnosis was 27.1 months (range 0-225.5) and median follow-up duration was 88.5 months (range 0-211.6). Overall, 32 patients died, of whom 17, 11, 1, and 3 died of relapse, progressive disease, second malignant neoplasm, and treatment-related mortality. Five-year overall survival and event free survival were 97.2% and 84.8% in WT, 90.6% and 82.1% in RCC, 81.1% and 63.6% in CCSK, 60.3% and 56.2% in MRTK, and 100% and 91.7% in CMN, respectively (p < 0.001).

Conclusion:
The pediatric renal tumor types in Korea are similar to those previously reported in other countries. WT accounted for a large proportion and survival was excellent. Non-Wilms renal tumors included a variety of tumors and showed inferior outcome, especially MRTK. Further efforts are necessary to optimize the treatment and analyze the genetic characteristics of pediatric renal tumors in Korea.
Keimyung Author(s)(Kor)
심예지
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?doi=10.4143/crt.2022.073
DOI
10.4143/crt.2022.073
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44727
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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