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Clinical and Prognostic Values of TRPM7 in Colon and Rectal Cancers

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Author(s)
Jun-Chae LeeAn-Na BaeHa-Jin LeeJae-Ho Lee
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Medicina (Kaunas)
Issued Date
2022
Volume
58
Issue
11
Keyword
(APC)(KRAS)(p53)The Cancer Genome Atlas (TCGA)colorectal cancer (CRC)transient receptor potential melastatin 7 (TRPM7)
Abstract
Background and Objectives:
Transient receptor potential melastatin 7 (TRPM7) is a unique channel protein, and functionally responsible for transportation of calcium and magnesium. Physiologically, the TRPM7 channel is involved in homeostasis of calcium and magnesium, and cell survival. TRPM7 expression is up-regulated in many cancers as malignant behaviors of cancer cells, and its deficiency suppresses their growth.

Materials and Methods:
In this study, we aimed to analyze clinical and prognostic characteristics of TRPM7 expression in colorectal cancers (CRC) using The Cancer Genome Atlas.

Results:
High expression of TRPM7 was observed in younger patients with rectal cancer (p = 0.0002). By quantitative correlation analysis, TRPM7 was negatively correlated with age (R = −0.239, p = 0.003) and p53 (R = −0.240, p = 0.002). Furthermore, it was positively correlated with APC expression (R = 0.534, p < 0.001) and KRAS expression (R = 0.319, p < 0.001). In colon cancer, there were no variables that showed a significant correlation with TRPM7. Survival analysis found that TRPM7 expression did not have any prognostic value in colon and rectal cancers.

Conclusions:
Our study highlights that TRPM7 expression in CRC, particularly in rectal cancer, may be a potential marker. Future studies are needed to provide deeper insights into the role of TRPM7 in rectal cancer.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1648-9144
Source
https://www.mdpi.com/1648-9144/58/11/1582
DOI
10.3390/medicina58111582
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44773
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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