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Clinical Characteristics of TZAP (ZBTB48) in Hepatocellular Carcinomas from Tissue, Cell Line, and TCGA

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Author(s)
Soo-Jung JungSo-Hyun KilHye Won LeeTae In ParkYun-Han LeeJongwan KimJae-Ho Lee
Keimyung Author(s)
Lee, Jae HoLee, Hye WonLee, Yun Han
Department
Dept. of Anatomy (해부학)
Dept. of Pathology (병리학)
Dept. of Molecular Medicine (분자의학)
Journal Title
Medicina (Kaunas)
Issued Date
2022
Volume
58
Issue
12
Keyword
TZAPZBTB48hepatocellular carcinomatelomere
Abstract
Background and Objectives:
ZBTB48 is a telomere-related protein that has been renamed telomeric zinc finger-associated protein (TZAP). It favorably binds to elongated telomeres to regulate their appropriate length. However, TZAP expression has not been investigated in hepatocellular carcinomas (HCC).

Materials and Methods:
The clinical significance of TZAP expression in 72 HCC was investigated. Additionally, its findings were supported by open big data and cancer cell lines.

Results:
TZAP expression level was not associated with the clinical parameters of HCC. TZAP expression induced a poorer survival result (overall survival, p = 0.020; disease-free survival, p = 0.012). TCGA data showed TZAP expression was more frequently found in HCCs with hepatitis C infection (p = 0.023). However, TCGA data revealed that TZAP expression did not predict HCC prognosis. In a cell line study, TZAP inhibition via siRNA suppressed PLC/PRF/5 cell growth; however, cell viability was increased in HepG2 cells.

Conclusions:
We presented the clinical and prognostic values of TZAP expression in HCC tissues and cancer cell lines. Additionally, the TCGA results also revealed a significant role for TZAP expression. TZAP expression may involve HCC progression and its prognosis.
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