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유전 요인과 생활환경 요인의 상호작용이 제2형 당뇨병 발생에 미치는 영향: 한국인유전체역학 조사사업(KoGES) 자료를 이용하여

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Author(s)
Sujin HyunSangeun Jun
Keimyung Author(s)
Jun, Sang Eun
Department
Dept. of Nursing (간호학)
Journal Title
J Korean Biol Nurs Sci
Issued Date
2023
Volume
25
Issue
1
Keyword
Type 2 diabetes mellitusGeneLifestyleGene-Environment Interaction
Abstract
Purpose:
This study focused on identifying the interaction effects of genetic and lifestyle-environmental factors on the development of type 2 diabetes mellitus (T2D).

Methods:
Study subjects were selected from the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2014. Data on genetic variations, anthropometric measurements, biochemical data, and seven lifestyle factors (diet, physical activity, alcohol drinking, smoking, sleep, depression, and stress) were obtained from 4,836 Koreans aged between 40 and 59 years, including those with T2D at baseline (n = 1,209), newly developed T2D (n = 1,298) and verified controls (n = 3,538). The genetic risk score (GRS) was calculated by using 11 single-nucleotide polymorphisms (SNPs) related to T2D development and the second quartile was used as the reference category. A Cox proportional hazards regression model was used to evaluate the associations of GRS and lifestyle factors with T2D risk, controlling for covariates.

Results:
Multivariate regression analysis revealed that GRS was the strongest risk factor for T2D, and body mass index (BMI), smoking, drinking, and spicy food preference also increased the risk. Lifestyle/environmental factors that showed significant interactions with GRS were BMI, current smoking, current drinking, fatty food preference, and spicy food preference.

Conclusions:
Interactions between genetic factors and lifestyle/environmental factors were associated with an increased risk of T2D. The results will be useful to provide a new perspective on genetic profiling for the earlier detection of T2D risk and clues for personalized interventions, which might be more effective prevention strategies or therapies in individuals with a genetic predisposition to T2D.
Alternative Title
Effects of gene-lifestyle environment interactions on type 2 diabetes mellitus development: an analysis using the Korean Genome and Epidemiology Study data
Keimyung Author(s)(Kor)
전상은
Publisher
College of Nursing (간호대학)
Type
Article
ISSN
2383-6423
Source
https://jkbns.org/journal/view.php?doi=10.7586/jkbns.23.353
DOI
10.7586/jkbns.23.353
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44799
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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