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Comparison of Treatment Patterns and Clinical Outcomes by Gender in Locally Advanced Head and Neck Squamous Cell Carcinoma (KCSG HN13-01)

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Author(s)
Yun-Gyoo LeeEun Joo KangBhumsuk KeamJin-Hyuk ChoiJin-Soo KimKeon Uk ParkKyoung Eun LeeKeun-Wook LeeMin Kyoung KimHee Kyung AhnSeong Hoon ShinHye Ryun KimSung-Bae KimHyo Jung KimHwan Jung Yun
Keimyung Author(s)
Park, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancers (Basel)
Issued Date
2023
Volume
15
Issue
2
Keyword
clinical outcomegenderlocally advanced head and neck squamous cell carcinoma
Abstract
We aimed to compare treatment modalities and outcomes by gender in patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We characterized the sex-specific differences and compared the overall survival (OS) between male and female patients in a multicenter cohort of LA-HNSCC. To minimize the observed confounding, propensity score matching was utilized. The study included 445 patients; 385 (86.5%) were men and 60 (13.5%) were women. In terms of age, smoking habits, drinking habits, and primary tumor locations, there was a significant imbalance in sex before the matching. Propensity score matching yielded 60 patient pairs, with no statistical difference between the sexes in terms of their characteristics. As for the treatment strategies, there were no significant differences between the sexes before (p = 0.260) and after (p = 0.585) the propensity score matching. When comparing the survival probabilities between the sexes, OS was not significantly different in the overall (HR 1.02; 95% CI 0.59-1.76; p = 0.938) and propensity-score-matched population (HR 1.46; 95% CI 0.68-3.17; p = 0.331). These results suggest that there was no difference in prognosis by gender in the treatment modalities and outcomes of LA-HNSCC in real-world practice.
Keimyung Author(s)(Kor)
박건욱
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2072-6694
Source
https://www.mdpi.com/2072-6694/15/2/471
DOI
10.3390/cancers15020471
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44833
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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