계명대학교 의학도서관 Repository

Diabetes, Atherosclerosis, and Stenosis by AI

Metadata Downloads
Author(s)
Rebecca A JonasTami R CrabtreeRobert S JenningsHugo MarquesRichard J KatzHyuk-Jae ChangWijnand J StuijfzandAlexander R van RosendaelJung Hyun ChoiJoon-Hyung DohAe-Young HerBon-Kwon KooChang-Wook NamHyung-Bok ParkSang-Hoon ShinJason ColeAlessia GimelliMuhammad Akram KhanBin LuYang GaoFaisal NabiRyo NakazatoU Joseph SchoepfRoel S DriessenMichiel J BomRandall C ThompsonJames J JangMichael RidnerChris RowanErick AvelarPhilippe GénéreuxPaul KnaapenGuus A de WaardGianluca PontoneDaniele AndreiniMouaz H Al-MallahMarco GuglielmoJeroen J BaxJames P EarlsJames K MinAndrew D ChoiTodd C Villines
Keimyung Author(s)
Nam, Chang Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Care
Issued Date
2023
Volume
46
Issue
2
Abstract
Objective:
This study evaluates the relationship between atherosclerotic plaque characteristics (APCs) and angiographic stenosis severity in patients with and without diabetes. Whether APCs differ based on lesion severity and diabetes status is unknown.

Research design and methods:
We retrospectively evaluated 303 subjects from the Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia (CREDENCE) trial referred for invasive coronary angiography with coronary computed tomographic angiography (CCTA) and classified lesions as obstructive (≥50% stenosed) or nonobstructive using blinded core laboratory analysis of quantitative coronary angiography. CCTA quantified APCs, including plaque volume (PV), calcified plaque (CP), noncalcified plaque (NCP), low-density NCP (LD-NCP), lesion length, positive remodeling (PR), high-risk plaque (HRP), and percentage of atheroma volume (PAV; PV normalized for vessel volume). The relationship between APCs, stenosis severity, and diabetes status was assessed.

Results:
Among the 303 patients, 95 (31.4%) had diabetes. There were 117 lesions in the cohort with diabetes, 58.1% of which were obstructive. Patients with diabetes had greater plaque burden (P = 0.004). Patients with diabetes and nonobstructive disease had greater PV (P = 0.02), PAV (P = 0.02), NCP (P = 0.03), PAV NCP (P = 0.02), diseased vessels (P = 0.03), and maximum stenosis (P = 0.02) than patients without diabetes with nonobstructive disease. APCs were similar between patients with diabetes with nonobstructive disease and patients without diabetes with obstructive disease. Diabetes status did not affect HRP or PR. Patients with diabetes had similar APCs in obstructive and nonobstructive lesions.

Conclusions:
Patients with diabetes and nonobstructive stenosis had an association to similar APCs as patients without diabetes who had obstructive stenosis. Among patients with nonobstructive disease, patients with diabetes had more total PV and NCP.
Keimyung Author(s)(Kor)
남창욱
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1935-5548
Source
https://diabetesjournals.org/care/article/46/2/416/148227/Diabetes-Atherosclerosis-and-Stenosis-by-AI
DOI
10.2337/dc21-1663
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44835
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.