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Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015-2017 Korean National Environmental Health Survey

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Author(s)
Jin-Wook ChungDilaram AcharyaJitendra Kumar SinghJoon Sakong
Keimyung Author(s)
Chung, Jin-Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
Int J Environ Res Public Health
Issued Date
2023
Volume
20
Issue
4
Keyword
Korean adultsalanine aminotransferaseaspartate aminotransferase blood mercury level
Abstract
Increased liver enzymes as a result of exposure to mercury and their toxic effects are not well understood in Korea at the population level. The effect of blood mercury concentration on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was evaluated after adjusting for sex, age, obesity, alcohol consumption habit, smoking, and exercise parameters in 3712 adults. The risk of abnormal liver function was measured using a multiple logistic regression analysis. Blood mercury concentration was divided into quartiles, and liver enzyme levels were compared for each quartile. ALT and AST levels were 10-20% higher in the second, third, and fourth quartiles compared to the first quartile. The risk of liver dysfunction or elevated liver enzymes was significantly higher in the second, third, and fourth quartiles than in the first quartile. As blood mercury levels increased, liver enzymes and mercury-induced hepatotoxicity increased. The increase in liver enzymes caused by mercury was more pronounced in the low-mercury concentration range. To reduce the long-standing problem of abnormal liver enzymes and liver function in Korea and other similar settings, it is important to decrease exposure to mercury through effective implementation of specific health and environmental strategies.
Keimyung Author(s)(Kor)
정진욱
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1660-4601
Source
https://www.mdpi.com/1660-4601/20/4/3290
DOI
10.3390/ijerph20043290
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44843
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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