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USP41 Enhances Epithelial-Mesenchymal Transition of Breast Cancer Cells through Snail Stabilization

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Author(s)
Ji-Yun YoonSeung-Un SeoSeon-Min WooTaeg-Kyu Kwon
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Int J Mol Sci
Issued Date
2023
Volume
24
Issue
2
Keyword
EMTUSP41breast cancerdeubiquitinasesnail
Abstract
Ubiquitination, one of many post-translational modifications, causes proteasome-mediated protein degradation by attaching ubiquitin to target proteins. Multiple deubiquitinases inhibit the ubiquitination pathway by removing the ubiquitin chain from protein, thus contributing to the stabilization of substrates. USP41 contributes to invasion, apoptosis and drug resistance in breast and lung cancer cells. However, the detailed mechanism and role of USP41 in breast cancer have not been elucidated. USP41 was overexpressed and showed poor prognosis according to the aggressive phenotype of breast cancer cells. Knockdown of USP41 inhibited migration and growth of breast cancer cells, whereas overexpression of USP41 increased cell growth and migration. In addition, depletion of USP41 downregulated Snail protein expression, an epithelial-mesenchymal transition marker, but not mRNA expression. Furthermore, USP41 interacted with and inhibited ubiquitination of Snail, resulting in the increase in Snail stabilization. Therefore, these data demonstrated that USP41 increases migration of breast cancer cells through Snail stabilization.
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1422-0067
Source
https://www.mdpi.com/1422-0067/24/2/1693
DOI
10.3390/ijms24021693
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44844
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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