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Inflammatory bowel disease-associated intestinal fibrosis

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Author(s)
Ji Min ParkJeongseok KimYoo Jin LeeSung Uk BaeHye Won Lee
Keimyung Author(s)
Kim, Jeong SeokLee, Yoo JinBae, Sung UkLee, Hye Won
Department
Dept. of Internal Medicine (내과학)
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Journal Title
J Pathol Transl Med
Issued Date
2023
Volume
57
Issue
1
Keyword
Colitis, ulcerativeCrohn diseaseFibrosisInflammatory bowel disease
Abstract
Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix following chronic inflammation, and this replacement of organ tissue with fibrotic tissue causes a loss of function. Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, and intestinal fibrosis is common in IBD patients, resulting in several complications that require surgery, such as a stricture or penetration. This review describes the pathogenesis and various factors involved in intestinal fibrosis in IBD, including cytokines, growth factors, epithelial-mesenchymal and endothelial-mesenchymal transitions, and gut microbiota. Furthermore, histopathologic findings and scoring systems used for stenosis in IBD are discussed, and differences in the fibrosis patterns of ulcerative colitis and Crohn's disease are compared. Biomarkers and therapeutic agents targeting intestinal fibrosis are briefly mentioned at the end.
Keimyung Author(s)(Kor)
김정석
이유진
배성욱
이혜원
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2383-7845
Source
https://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2022.11.02
DOI
10.4132/jptm.2022.11.02
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44859
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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