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Human induced pluripotent stem cell line YCMi007-A generated from a dilated cardiomyopathy patient with a heterozygous dominant c.613C>T (p. Arg205Trp) variant of the TNNT2 gene

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Author(s)
Sae-Bom JeonHyoeun KimKyeong-Hyeon ChunJaewon OhChulan KwonHyo-Kyoung ChoiSangwoo KimHyoung-Pyo KimIn-Cheol KimJung-Yoon YooSahng Wook ParkSeok-Min KangSeung-Hyun Lee
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Stem Cell Res
Issued Date
2023
Volume
67
Abstract
Cardiac muscle troponin T protein binds to tropomyosin and regulates the calcium-dependent actin-myosin interaction on thin filaments in cardiomyocytes. Recent genetic studies have revealed that TNNT2 mutations are strongly linked to dilated cardiomyopathy (DCM). In this study, we generated YCMi007-A, a human induced pluripotent stem cell (hiPSC) line from a DCM patient with a p. Arg205Trp mutation in the TNNT2 gene. The YCMi007-A cells show high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Thus, YCMi007-A-an established iPSC-could be useful for the investigation of DCM.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1876-7753
Source
https://www.sciencedirect.com/science/article/pii/S187350612300034X?via%3Dihub
DOI
10.1016/j.scr.2023.103048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44879
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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