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Effectiveness of Adding Docetaxel to Androgen Deprivation Therapy for Metastatic Hormone-Sensitive Prostate Cancer in Korean Real-World Practice

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Author(s)
Kwonoh ParkJin Young KimInkeun ParkSeong Hoon ShinHyo Jin LeeJae Lyun Lee
Keimyung Author(s)
Kim, Jin Young
Department
Dept. of Internal Medicine (내과학)
Journal Title
Yonsei Med J
Issued Date
2023
Volume
64
Issue
2
Keyword
Docetaxelchemotherapyhormone-sensitiveprostate cancerprostatic neoplasms
Abstract
Purpose:
Evidence in favor of adding docetaxel in treatment of metastatic hormone-sensitive prostate cancer (mHSPC) has led to docetaxel in conjunction with androgen deprivation therapy (ADT) as standard therapy. The aim of this study was to examine the effectiveness of docetaxel with ADT for Korean patients with mHSPC in real-world practice.

Materials and methods:
A retrospective cohort study was performed at six Korean hospitals for patients with mHSPC treated with docetaxel plus ADT. Patients were treated every 3 weeks for up to six cycles with 75 mg/m² of docetaxel. The primary endpoint was time to castration resistant prostate cancer (CRPC).

Results:
This study included 46 eligible patients from June 2016 to February 2021. Median age was 68.5 years (range, 52-84) and all patients present with de novo M1 with high-volume disease. The median prostate-specific antigen (PSA) level at ADT initiation was 205.4 (7.7-1933) ng/mL, and time from ADT to docetaxel was 2.4 months (0-5.3). All six planned cycles of docetaxel were delivered in 36 patients (78%), 7 patients (15%) discontinued treatment due to adverse events, and 3 patients (7%) discontinued due to progression. At the time of the analysis, CRPC had developed in 34 patients (74%), and the median time to CRPC was 18.0 (95% confidence interval, 14.1-21.9) months. PSA <0.2 ng/mL was achieved in 11 patients (24%) after 6 months of ADT and in 10 patients (22%) after 12 months. At last follow-up, 35 patients (76%) were alive; the median overall survival was not reached.

Conclusion:
The effect of docetaxel combined with ADT for Korean patients with mHSPC is comparable with prior results in Western studies.
Keimyung Author(s)(Kor)
김진영
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1976-2437
Source
https://eymj.org/DOIx.php?id=10.3349/ymj.2022.0244
DOI
10.3349/ymj.2022.0244
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44884
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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