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Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis

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Author(s)
Kwangho KimTae Young RyuEunsun JungTae-Su HanJinkwon LeeSeon-Kyu KimYu Na RohMoo-Seung LeeCho-Rok JungJung Hwa LimRyuji HamamotoHye Won LeeKeun HurMi-Young SonDae-Soo KimHyun-Soo Cho
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Exp Mol Med
Issued Date
2023
Volume
55
Issue
5
Abstract
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regulates metastasis has not been fully elucidated. Here, we found that the histone methyltransferase SMYD2 is overexpressed in lung cancer and that knockdown of SMYD2 could reduce the rates of cell migration and invasion in lung cancer cell lines via direct downregulation of SMAD3 via SMYD2-mediated epigenetic regulation. Furthermore, using an in vitro epithelial-mesenchymal transition (EMT) system with a Transwell system, we generated highly invasive H1299 (In-H1299) cell lines and observed the suppression of metastatic features by SMYD2 knockdown. Finally, two types of in vivo studies revealed that the formation of metastatic tumors by shSMYD2 was significantly suppressed. Thus, we suggest that SMYD2 is a potential metastasis regulator and that the development of SMYD2-specific inhibitors may help to increase the efficacy of lung cancer treatment.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2092-6413
Source
https://www.nature.com/articles/s12276-023-00987-1
DOI
10.1038/s12276-023-00987-1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44893
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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