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Prediction of Oncotype DX Recurrence Score Using Clinicopathological Variables in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer

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Author(s)
Min Chong KimSun Young KwonJung Eun ChoiSu Hwan KangYoung Kyung Bae
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
J Breast Cancer
Issued Date
2023
Volume
26
Issue
2
Keyword
Breast NeoplasmsDrug TherapyKi-67 AntigenReceptors, ProgesteroneRecurrence
Abstract
Purpose:
Oncotype DX (ODX) is a well-validated multigene assay that is increasingly used in Korean clinical practice. This study aimed to develop a clinicopathological prediction (CPP) model for the ODX recurrence scores (RSs).

Methods:
A total of 297 patients (study group, n = 175; external validation group, n = 122) with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, T1-3N0-1M0 breast cancer, and available ODX test results were included in the study. Risk categorization as determined by ODX RSs concurred with the TAILORx study (low-risk, RS ≤ 25; high-risk, RS > 25). Univariate and multivariate logistic regression analyses were used to assess the relationships between clinicopathological variables and risk stratified by the ODX RSs. A CPP model was constructed based on regression coefficients (β values) for clinicopathological variables significant by multivariate regression analysis.

Results:
Progesterone receptor (PR) negativity, high Ki-67 index, and nuclear grade (NG) 3 independently predicted high-risk RS, and these variables were used to construct the CPP model. The C-index, which represented the discriminatory ability of our CPP model for predicting a high-risk RS, was 0.915 (95% confidence interval [CI], 0.859-0.971). When the CPP model was applied to the external validation group, the C-index was 0.926 (95% CI, 0.873-0.978).

Conclusion:
Our CPP model based on PR, Ki-67 index, and NG could aid in the selection of patients with breast cancer requiring an ODX test.
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2092-9900
Source
https://ejbc.kr/DOIx.php?id=10.4048/jbc.2023.26.e19
DOI
10.4048/jbc.2023.26.e19
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44894
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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