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Effect of Testosterone Supplementation on Cognition in Elderly Men: A Systematic Meta-Analysis

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Author(s)
Seung Wan HongYoon Jeong ChoJae Hyuck LeeYoung Sung SuhDae Hyun Kim
Keimyung Author(s)
Lee, Jae HyuckSuh, Young SungKim, Dae Hyun
Department
Dept. of Family Medicine (가정의학)
Journal Title
임상노인의학회지
Issued Date
2023
Volume
24
Issue
1
Keyword
AgingCognitionHormone replacement therapyTestosterone
Abstract
Background:
Cognitive function is an important issue in aging societies. Testosterone levels and cognitive function are known to be correlated; however, the clinical conclusions remain controversial. This study aimed to investigate whether testosterone supplementation improve cognitive function in adult men through a systematic meta-analysis.

Methods:
A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The PubMed, Cochrane Library, and Embase databases were searched. Literature search, study identification, and data extraction were performed between December 2019 and March 2021.

Results:
A total of 15 studies were included in the meta-analysis. The sample sizes of the selected studies varied from 11 to 493. There were no significant differences in cognitive speed (standardized mean difference [SMD]=−0.05; 95% confidence interval [CI], −0.26 to 0.16), immediate verbal memory function (SMD=0.07; 95% CI, −0.05 to 0.20), immediate visual memory function (SMD=−0.01; 95% CI, −0.15 to 0.13), working memory function (SMD=−0.04; 95% CI, −0.42 to 0.35), delayed memory function (SMD=−0.02; 95% CI, −0.14 to 0.10), executive function (SMD=0.03; 95% CI, −0.08 to 0.15), perception (SMD=−0.13; 95% CI, −0.37 to 0.11), cognitive inhibition (SMD=−0.13; 95% CI, −0.49 to 0.23), visual attention (SMD=−0.02; 95% CI, −0.16 to 0.11), and cognitive status scores (SMD=−0.02; 95% CI, −0.18 to 0.14).

Conclusion:
The findings of this study indicate that there is a lack of evidence that testosterone administration has an effect on preventing cognitive decline. Therefore, testosterone use to prevent cognitive decline may not be recommended.
Keimyung Author(s)(Kor)
이재혁
서영성
김대현
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2383-5699
Source
http://www.ekjcg.org/journal/view.html?doi=10.15656/kjcg.2023.24.1.24
DOI
10.15656/kjcg.2023.24.1.24
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44910
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
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