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Role of club cell 16-kDa secretory protein in asthmatic airways

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Author(s)
Chang-Gyu JungThi Bich Tra CaoQuang Luu QuocEun-Mi YangGa-Young BanHae-Sim Park
Keimyung Author(s)
Jung, Chang Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Clin Exp Allergy
Issued Date
2023
Volume
53
Issue
6
Keyword
CC16airways obstructionasthmahouse dust miteinflammationremodellingsmall airways dysfunction
Abstract
Background:
Club cell 16-kDa secretory protein (CC16) is a pneumoprotein and functions as an anti-inflammatory or antioxidant protein. However, altered levels of serum CC16 as well as their effect on airways inflammation have not been fully evaluated.

Methods:
We recruited 63 adult asthmatics on maintenance medications and 61 healthy controls (HCs). The asthmatic subjects were divided into two groups according to the result of bronchodilator responsiveness (BDR) test: the present BDR (n = 17) and absent BDR (n = 46) groups. Serum CC16 levels were measured by ELISA. As an in vitro study, the effect of Dermatophagoides pteronyssinus antigen 1 (Der p1) on the production of CC16 in airways epithelial cells (AECs) according to a time-dependent manner was assessed; the effects of CC16 protein on oxidative stress system, airways inflammation and remodelling were tested.

Results:
Serum CC16 levels showed significantly higher in the asthmatics than in the HCs (p < .001) with a positive correlation with FEV1 % (r = .352, p = .005). The present BDR group had significantly lower levels of serum CC16, FEV1 % and MMEF%, but showed higher level of FeNO than the absent BDR group. Serum CC16 levels (below 496.0 ng/mL) could discriminate the present BDR group from the absent BDR group (area under the curve = 0.74, p = .004). In vitro testing demonstrated that Der p1 exposure significantly induced CC16 release from AECs for 1 h, which was progressively decreased after 6 h and followed by MMP-9 and TIMP-1 production. These findings were associated with oxidant/antioxidant disequilibrium and restored by CC16 treatment (but not dexamethasone).

Conclusion:
Decreased CC16 production contributes to persistent airways inflammation and lung function decline. CC16 may be a potential biomarker for asthmatics with BDR.
Keimyung Author(s)(Kor)
정창규
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1365-2222
Source
https://onlinelibrary.wiley.com/doi/10.1111/cea.14315
DOI
10.1111/cea.14315
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/44964
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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