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Expansion and characterization of regulatory T cell populations from Korean kidney transplant recipients

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Author(s)
Jin Hyuk PaekYe Na KimHo Sik ShinYeonsoon JungHark Rim
Keimyung Author(s)
Paek, Jin Hyuk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Medicine (Baltimore)
Issued Date
2023
Volume
102
Issue
11
Abstract
The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot induce immune tolerance, and their nonspecific immunosuppressive effects result in many adverse effects. Regulatory T cells (Tregs) play crucial roles in controlling all specific immune responses. This study evaluated the distribution of Tregs and their effects on kidney allograft function in Korean KT recipients. We enrolled 113 KT recipients with stable graft function. The differentiation and expansion of Tregs were examined by flow cytometry to compare the Tregs subpopulations. Among the 113 patients, 73 (64.6%) were males, and the mean follow-up period from KT to Tregs collection was 147.5 + 111.3 months. Patients receiving lower doses of cyclosporine had higher proportions of Tregs than those with higher doses of cyclosporine (36.3 + 21.6 vs 17.0 + 12.7, P = .010, respectively). Patients taking cyclosporine tended to have higher Tregs numbers than those taking tacrolimus (94.7 + 158.1 vs 49.3 + 69.4, P = .095, respectively). However, no significant association was observed between Tregs and allograft dysfunction in the cox proportional hazard model. Tregs counts may be associated with the type and dose of immunosuppressants. However, no significant relationship was found between Tregs and kidney allograft function in stable KT recipients.
Keimyung Author(s)(Kor)
백진혁
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1536-5964
Source
https://journals.lww.com/md-journal/Fulltext/2023/03170/Expansion_and_characterization_of_regulatory_T.32.aspx
DOI
10.1097/MD.0000000000033058
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45007
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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