계명대학교 의학도서관 Repository

Risk and characteristics of Bell's palsy in adults as an adverse event following COVID-19 vaccination: a retrospective study

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Author(s)
Sohyeon KimMinsung KangJin-Sung ParkHung Youl Seok
Keimyung Author(s)
Seok, Hung Youl
Department
Dept. of Neurology (신경과학)
Journal Title
Acta Neurol Belg
Issued Date
2023
Volume
123
Issue
6
Keyword
Bell’s palsyCOVID-19COVID-19 vaccinesSARS-CoV-2Vaccination
Abstract
Background:
Although an association between COVID-19 vaccination and Bell's palsy (BP) has been reported, a clear causal relationship has not been elucidated. We investigated the risk and clinical characteristics of BP after COVID-19 vaccination.

Methods:
This retrospective chart review evaluated the association between COVID-19 vaccination and BP by comparing the number of patients diagnosed with BP during the pre-COVID-19 vaccination period (March 2018-February 2021) and the COVID-19 mass vaccination period (March 2021-February 2022). We then compared vaccine-related (time between vaccination and BP onset < 42 days) and -unrelated (time interval ≥ 42 days or non-vaccination) clinical characteristics in newly diagnosed patients with BP.

Results:
BP occurred more during the COVID-19 vaccination period than in the previous three pre-vaccination years. Thirteen patients developed BP within 42 days of vaccination. All patients, except one, developed BP after mRNA-based vaccination, with most cases (9/13, 69.2%) occurring after the second or third dose. Thirteen patients with vaccine-related BP were younger (age 43.92 ± 13.14 vs. 54.32 ± 16.01 years; p = 0.033) and more frequently experienced taste changes (58.8% vs. 10.9%; p = 0.002) than 52 patients with vaccine-unrelated BP. Patients with vaccine-related BP had a greater likelihood of good and faster (p = 0.042) facial nerve function recovery than those with vaccine-unrelated BP (100% vs. 78%).

Conclusion:
COVID-19 vaccines, especially mRNA-based vaccines, may be associated with BP cases with distinctive clinical characteristics, which occur more frequently in young individuals, are frequently accompanied by taste changes, and have fast and good recovery.
Keimyung Author(s)(Kor)
석흥열
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2240-2993
Source
https://link.springer.com/article/10.1007/s13760-023-02204-2
DOI
10.1007/s13760-023-02204-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45101
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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