계명대학교 의학도서관 Repository

Prevalence and Prognostic Implications of Worsening Renal Function After Acute Myocardial Infarction

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Author(s)
Guiyue JinSeok-Woo SeongMi Joo KimKye Taek AhnSeon-Ah JinJoo-Yong HahnHyeon-Cheol GwonSeung-Ho HurSeung-Woon RhaChang-Hwan YoonMyung Ho JeongJang-Whan BaePil Sang SongJin-Ok Jeong
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Am J Cardiol
Issued Date
2023
Volume
200
Abstract
We sought to investigate the relation between worsening renal function (WRF) at 1-year follow-up and clinical outcomes at 3 years after acute myocardial infarction (AMI). We analyzed data from 13,104 patients enrolled in the national AMI registry from November 2011 to December 2015. Patients with all-cause death, recurrent myocardial infarction (re-MI), and rehospitalization for heart failure at 1-year follow-up after AMI were excluded. A total of 6,235 patients were extracted and divided into WRF and non-WRF groups. WRF was defined as a ≥25% decrease in estimated glomerular filtration rate (eGFR) from baseline to 1-year follow-up. The primary outcome was 3-year major adverse cardiac events, a composite of all-cause death, re-MI, and rehospitalization for heart failure. On average, a -1.5 ml/min/1.73 m2/y rate of decrease in eGFR was exhibited, and 575 patients (9.2%) exhibited WRF at 1-year follow-up. After multiple adjustments, WRF at 1-year follow-up was independently associated with increased risks of major adverse cardiac events (adjusted hazard ratio 1.498, 95% confidence interval 1.113 to 2.016, p = 0.01), all-cause death, and re-MI at 3-year follow-up. Older age, female, diabetes mellitus, hypertension, non-ST-segment elevation AMI, anterior AMI, anemia, left ventricular ejection fraction <35%, and baseline eGFR <30 ml/min/1.73 m2 were identified as independent predictors of WRF after AMI. In conclusion, WRF at 1-year follow-up after AMI intuitively seems like a risk marker indicating multiple co-morbidities. Monitoring serum creatinine in patients at 1-year follow-up after AMI may help to identify those who are at the highest risk and guide effective long-term therapeutics.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1879-1913
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0002914923002898
DOI
10.1016/j.amjcard.2023.05.011
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45164
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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