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Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity

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Author(s)
Rebecca JonasToral PatelTami R CrabtreeRobert S JenningsRan HeoHyung-Bok ParkHugo MarquesHyuk-Jae ChangWijnand J StuijfzandAlexander R van RosendaelJung Hyun ChoiJoon-Hyung DohAe-Young HerBon-Kwon KooChang-Wook NamSang-Hoon ShinJason ColeAlessia GimelliMuhammad Akram KhanBin LuYang GaoFaisal NabiMouaz H Al-MallahRyo NakazatoU Joseph SchoepfRoel S DriessenMichiel J BomRandall C ThompsonJames J JangMichael RidnerChris RowanErick AvelarPhilippe GénéreuxPaul KnaapenGuus A de WaardGianluca PontoneDaniele AndreiniJeroen J BaxAndrew D ChoiJames P EarlsUdo HoffmannJames K MinTodd C Villines
Keimyung Author(s)
Nam, Chang Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
Am J Cardiol
Issued Date
2023
Volume
204
Abstract
It is unknown whether gender influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial, all of whom underwent coronary computed tomographic angiography and clinically indicated nonemergent invasive coronary angiography upon study enrollment. Index tests were interpreted by 2 blinded core laboratories, one of which performed quantitative coronary computed tomographic angiography using an artificial intelligence application to characterize and quantify APCs, including percent atheroma volume (PAV), low-density noncalcified plaque (LD-NCP), noncalcified plaque (NCP), calcified plaque (CP), lesion length, positive arterial remodeling, and high-risk plaque (a combination of LD-NCP and positive remodeling ≥1.10); the other classified lesions as obstructive (≥50% diameter stenosis) or nonobstructive (<50% diameter stenosis) based on quantitative invasive coronary angiography. The relation between APCs and angiographic stenosis was further examined by gender. The mean age of the study cohort was 64.4 ± 10.2 years (29.0% female). In patients with obstructive disease, men had more LD-NCP PAV (0.5 ± 0.4 vs 0.3 ± 0.8, p = 0.03) and women had more CP PAV (11.7 ± 1.6 vs 8.0 ± 0.8, p = 0.04). Obstructive lesions had more NCP PAV compared with their nonobstructive lesions in both genders, however, obstructive lesions in women also demonstrated greater LD-NCP PAV (0.4 ± 0.5 vs 1.0 ± 1.8, p = 0.03), and CP PAV (17.4 ± 16.5 vs 25.9 ± 18.; p = 0.03) than nonobstructive lesions. Comparing the composition of obstructive lesions by gender, women had more CP PAV (26.3 ± 3.4 vs 15.8 ± 1.5, p = 0.005) whereas men had more NCP PAV (33.0 ± 1.6 vs 26.7 ± 2.5, p = 0.04). Men had more LD-NCP PAV in nonobstructive lesions compared with women (1.2 ± 0.2 vs 0.6 ± 0.2, p = 0.02). In conclusion, there are gender-specific differences in plaque composition based on stenosis severity.
Keimyung Author(s)(Kor)
남창욱
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1879-1913
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0002914923005325
DOI
10.1016/j.amjcard.2023.07.004
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45165
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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