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Comparison of Retinal and Choroidal Microvasculature Changes in Monocular Amblyopic and Non-amblyopic Eyes following Short-term Patch Occlusion Treatment

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Author(s)
Jae-Gon KimSe Youp LeeDong Cheol Lee
Keimyung Author(s)
Lee, Se YupLee, Dong Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Curr Eye Res
Issued Date
2023
Volume
48
Issue
9
Keyword
Amblyopiachoriocapillarisoptical coherence tomographypatch occlusion treatmentretinal vasculature
Abstract
Purpose:
Our objective was to investigate whether there were differences in the short-term changes of retinal and choroidal microvasculature between amblyopic and non-amblyopic eyes after patch occlusion treatment in patients with monocular amblyopia. Additionally, we aimed to determine if these changes were associated with improvements in clinical parameters.

Methods:
We conducted a retrospective, longitudinal paired-eye case-control study by analyzing the medical records of patients under the age of 12 who had monocular amblyopia and underwent patch occlusion treatment for a duration of 2 to 12 months. Using optical coherence tomography angiography images, we compared the foveal avascular zone width, retinal blood vessel density (VD), choroidal thickness (CT), and choroidal vascularity index (CVI) in amblyopic and non-amblyopic eyes before and after patch occlusion treatment. We analyzed the correlations between the aforementioned parameters and changes in best-corrected visual acuity (BCVA) and stereopsis.

Results:
Overall, 114 eyes from 57 patients were enrolled. At baseline, parafoveal superficial plexus VD, foveal and parafoveal deep capillary plexus VD (DCPD) were lower by 0.994 ± 3.312% (p = .026), 2.403 ± 8.273% (p = .033), and 2.469 ± 4.095% (p < .001), respectively; CT was thicker by 30.6 ± 90.7 μm (p = .014); and CVI was higher by 1.920 ± 3.432% (p < 001) in the amblyopic eyes than in the non-amblyopic eyes. Following short-term patch occlusion treatment, foveal and parafoveal DCPD increased by 1.264 ± 3.829% (p = .017) and 1.028 ± 3.662% (p = .036), respectively, CT thinned by 15.5 ± 51.5 μm (p = .019), and CVI decreased by 1.296 ± 3.997% (p = .018) in the amblyopic eyes. Following patch occlusion treatment, as the foveal DCPD decreased and CVI increased, the BCVA improved (p = .017 and .035, respectively).

Conclusion:
Following patch occlusion treatment, increased foveal DCPD and decreased CVI were associated with improved BCVA.
Keimyung Author(s)(Kor)
이세엽
이동철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1460-2202
Source
https://www.tandfonline.com/doi/full/10.1080/02713683.2023.2222231
DOI
10.1080/02713683.2023.2222231
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45197
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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