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Safety and Clinical Outcomes of Insulin Degludec in Korean Patients with Diabetes in Real-World Practices: A Prospective, Observational Study

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Author(s)
Byung Wan LeeKyu Jeung AhnHo Chan ChoEun Young LeeKyungWan MinAmine DahaouiJin Sook JeongHyo Jin LimHak Chul Jang
Keimyung Author(s)
Cho, Ho Chan
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes Ther
Issued Date
2023
Volume
14
Issue
10
Keyword
Basal insulinDiabetesGlycemic controlInsulin treatmentReal-world practice
Abstract
Introduction:
To investigate the safety and effectiveness of insulin degludec (IDeg) in a real-world population of Korean patients with diabetes requiring insulin therapy.

Methods:
This was a multicenter, prospective, single-arm, open-label, non-interventional study. Patients aged ≥ 12 months and treated with previous glucose-lowering medications were eligible to switch to IDeg. The primary endpoint was the incidence of adverse events (AEs), and the secondary endpoints were changes in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial glucose (PPG), and target HbA1c < 7.0%.

Results:
In total, 3225 and 2450 patients were included in the safety analysis set (SAS) and effectiveness analysis set (EAS), respectively. The mean baseline HbA1c and duration of diabetes were 9.4% and 13.0 years, respectively. Adverse events were reported in 740 patients (22.9%); the majority were mild and resolved. Significant improvements were observed in HbA1c, FPG, and PPG at week 26 (all p < 0.0001). The target of HbA1c < 7% was achieved in 22.2% of patients at week 26.

Conclusion:
In real-world clinical practice, 26 weeks of IDeg treatment resulted in significant reductions in glycemic parameters with a low incidence of AEs in Korean patients with diabetes. No new safety signals were observed.

Clinical trials registry and registration number:
This trial is registered under ClinicalTrials.gov (NCT02779413) and the universal trial number is [U1111-1176-2287].
Keimyung Author(s)(Kor)
조호찬
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1869-6953
Source
https://link.springer.com/article/10.1007/s13300-023-01448-8
DOI
10.1007/s13300-023-01448-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45199
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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