계명대학교 의학도서관 Repository

Primary sclerosing cholangitis causally affects kidney function decline: A Mendelian randomization study

Metadata Downloads
Author(s)
Jeong Min ChoJung Hun KohSeong Geun KimSoojin LeeYaerim KimSemin ChoKwangsoo KimYong Chul KimSeung Seok HanHajeong LeeJung Pyo LeeKwon Wook JooChun Soo LimYon Su KimDong Ki KimSehoon Park
Keimyung Author(s)
Kim, Yae Rim
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Gastroenterol Hepatol
Issued Date
2023
Volume
39
Issue
1
Keyword
Chronic kidney failureGlomerular filtration rateKidney function testsMendelian randomization analysisPrimary sclerosing cholangitis
Abstract
Background and aim:
The causal linkage between primary sclerosing cholangitis (PSC) and kidney function is unexplored despite their potential for long-term detrimental effects on kidney function.

Methods:
Two-sample summary-level Mendelian randomization (MR) study was conducted to identify the association between PSC and kidney function. The genetic variants were extracted from the PSC-specific multi-trait analyzed genome-wide association study (GWAS) of European ancestry. Summary-level data for kidney function traits, including estimated glomerular filtration rate (eGFR), annual eGFR decline, and chronic kidney disease (CKD), were obtained from the CKDGen consortium. Multiplicative random-effects inverse-variance weighted (MR-IVW), and a series of pleiotropy-robust analyses were performed to investigate the causal effects and ascertain their robustness.

Results:
Significant causal associations between genetically predicted PSC and kidney function traits were identified. Genetically predicted PSC was associated with decreased log-transformed eGFR (MR-IVW; beta = -0.41%; standard error [SE] = 0.02%; P < 0.001), increased rate of annual eGFR decline (MR-IVW; beta = 2.43%; SE = 0.18%; P < 0.001), and higher risk of CKD (MR-IVW; odds ratio = 1.07; 95% confidence interval = 1.06-1.08; P < 0.001). The main findings were supported by pleiotropy-robust analysis, including MR-Egger with bootstrapped error and weighted median.

Conclusions:
Our study demonstrates that genetically predicted PSC is causally associated with kidney function impairment. Further studies are warranted to identify the underlying mechanisms.
Keimyung Author(s)(Kor)
김예림
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1440-1746
Source
https://onlinelibrary.wiley.com/doi/10.1111/jgh.16355
DOI
10.1111/jgh.16355
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45241
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.