계명대학교 의학도서관 Repository

Association between sclerostin levels and vascular outcomes in kidney transplantation patients

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Author(s)
Hee Byung KohJung Hwa RyuSeung-Seob KimMyung-Gyu KimJae Berm ParkChan Duk KimKyung Pyo KangHan RoSeung-Yeup HanKyu Ha HuhJaeseok Yang
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
J Nephrol
Issued Date
2023
Volume
36
Issue
7
Keyword
Abdominal aortic calcificationArterial stiffnessKidney transplantationPulse wave velocitySclerostin
Abstract
Background:
The impact of circulating sclerostin levels on vascular calcification has shown conflicting results depending on the target population and vascular anatomy. This study investigated the associations of sclerostin levels with vascular outcomes in kidney transplant patients.

Methods:
In a prospective observational study of the Korean Cohort Study for Outcome in Patients with Kidney Transplantation, 591 patients with serum sclerostin level data prior to transplantation were analyzed. The main predictor was the pre-transplant sclerostin level. Vascular outcomes were the abdominal aortic calcification score and brachial-ankle pulse wave velocity measured at pre-transplant screening and three and five years after kidney transplantation.

Results:
In linear regression analysis, sclerostin level positively correlated with changes in abdominal aortic calcification score between baseline and five years after kidney transplantation (coefficient of 0.73 [95% CI, 0.11-1.35] and 0.74 [95% CI, 0.06-1.42] for second and third tertiles, respectively, vs the first tertile). In a longitudinal analysis over five years, using generalized estimating equations, the coefficient of the interaction (sclerostin × time) was significant with a positive value, indicating that higher sclerostin levels were associated with faster increase in post-transplant abdominal aortic calcification score. Linear regression analysis revealed a positive association between pre-transplant sclerostin levels and changes in brachial-ankle pulse wave velocity (coefficient of 126.7 [95% CI, 35.6-217.8], third vs first tertile). Moreover, a significant interaction was identified between sclerostin levels and brachial-ankle pulse wave velocity at five years.

Conclusions:
Elevated pre-transplant sclerostin levels are associated with the progression of post-transplant aortic calcifications and arterial stiffness.
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1724-6059
Source
https://link.springer.com/article/10.1007/s40620-023-01732-7
DOI
10.1007/s40620-023-01732-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45250
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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