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Efficacy of Topical 0.05% Cyclosporine A for Ocular Surface Disease Related to Topical Anti-Glaucoma Medications

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Author(s)
Jae-Gon Kim , Jae-Hong An , Soon Young Cho , Chong Eun Lee , Kyu Young Shim , Jong Hwa Jun
Keimyung Author(s)
Cho, Soon YoungLee, Chong EunJun, Jong Hwa
Department
Dept. of Ophthalmology (안과학)
Journal Title
J Ocul Pharmacol Ther
Issued Date
2023
Volume
39
Issue
6
Keyword
antiglaucomabenzalkonium chloridecyclosporine Aocular surfacepreservative
Abstract
Purpose:
We aimed to determine the therapeutic efficacy of 0.05% topical cyclosporine A (CsA) for chronic ocular surface disease (OSD) in patients using benzalkonium chloride (BAK)-preserved antiglaucoma eye drops.

Methods:
A prospective, randomized, paired-eye, controlled clinical trial was conducted with participants who had been instilling at least one BAK-preserved topical antiglaucoma drug in both eyes for at least 6 months. Topical CsA was only applied in randomly selected unilateral eyes. Visual field (VF) indices, ocular surface parameters, tear meniscus height (TMH), and matrix metalloproteinase-9 (MMP-9) immunoassay were evaluated at baseline and at 2 and 4 months.

Results:
Seventy eyes from 35 participants were included in the study. The Schirmer I, tear breakup time, and TMH increased by 4.5 ± 8.6 mm (P < 0.01), 5.0 ± 5.3 s (P < 0.001), and 85.4 ± 159.0 μm (P < 0.01) in the treated eyes at 4 months from baseline, respectively. The ocular staining score and MMP-9 positivity in the treated eyes decreased by 2.2 ± 1.3 (P < 0.001) and 0.7 ± 0.9 points (P < 0.001), respectively, at 4 months. In untreated eyes, only TMH increased by 41.4 ± 92.1 μm (P = 0.016) from baseline to 4 months. In VF indices, the tracking failure frequency was 19.09% ± 21.62%, and the test duration was 336.0 ± 79.5 s in the treated eyes at 4 months, which were lower than 34.37% ± 23.13% (P < 0.001) and 375.9 ± 70.7 s (P < 0.05) in the nontreated eyes.

Conclusion:
Application of topical 0.05% CsA significantly improved the OSD parameters and the reliability indices of VF tests. This study was registered with the Clinical Research Information Service (CRIS) (number KCT0007124).
Keimyung Author(s)(Kor)
조순영
이종은
전종화
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1557-7732
Source
https://www.liebertpub.com/doi/10.1089/jop.2022.0183
DOI
10.1089/jop.2022.0183
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45254
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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