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Short-term effects of occlusion therapy and optical correction on microvasculature in monocular amblyopia: a retrospective case-control study

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Author(s)
Jae-Gon KimSe Youp LeeDong Cheol Lee
Keimyung Author(s)
Lee, Se YupLee, Dong Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Sci Rep
Issued Date
2023
Volume
13
Issue
1
Abstract
This retrospective longitudinal case-control study investigated the short-term effects of patch occlusion treatment compared with optical correction on the microvasculature in monocular amblyopia. We included patients with monocular amblyopia treated for 2-12 months; they were classified into two groups according to the treatment regimen: patch occlusion or optical correction. Children aged < 12 years who presented to our clinic for examination without amblyopia diagnosis were enrolled as the control group. Changes in retinal and choroid microvasculature according to treatment were examined, and the correlation between changes in microvasculature and improvement in best-corrected visual acuity (BCVA) was evaluated. There were 57, 35, and 41 patients in the patch occlusion, optical correction, and control groups, respectively (mean age, 6.4 ± 2.0 years). Both amblyopic groups showed changes in the foveal and parafoveal deep capillary plexus vessel density (DCPD), choroidal thickness, and choroidal vascularity index (CVI) following short-term treatment (mean, 4.5 months). In the patch occlusion group, BCVA improved as the foveal DCPD increased (P = 0.013) and the CVI decreased (P = 0.037). In the optical correction group, BCVA improved as the foveal and parafoveal DCPD increased (P = 0.009). Increased foveal DCPD following amblyopia treatment and decreased CVI by patch occlusion were associated with improved BCVA.
Keimyung Author(s)(Kor)
이세엽
이동철
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-023-38632-6
DOI
10.1038/s41598-023-38632-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45298
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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