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TNF in Human Tuberculosis: A Double-Edged Sword

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Author(s)
Jae-Min YukJin Kyung KimIn Soo KimEun-Kyeong Jo
Keimyung Author(s)
Kim, Jin Kyung
Department
Dept. of Microbiology (미생물학)
Journal Title
Immune Netw
Issued Date
2024
Volume
24
Issue
1
Keyword
TNF-alphaMycobacterium tuberculosisHost microbial interactionsAutophagyCell deathPathogenesis
Abstract
TNF, a pleiotropic proinflammatory cytokine, is important for protective immunity and immunopathology during Mycobacterium tuberculosis (Mtb) infection, which causes tuberculosis (TB) in humans. TNF is produced primarily by phagocytes in the lungs during the early stages of Mtb infection and performs diverse physiological and pathological functions by binding to its receptors in a context-dependent manner. TNF is essential for granuloma formation, chronic infection prevention, and macrophage recruitment to and activation at the site of infection. In animal models, TNF, in cooperation with chemokines, contributes to the initiation, maintenance, and clearance of mycobacteria in granulomas. Although anti-TNF therapy is effective against immune diseases such as rheumatoid arthritis, it carries the risk of reactivating TB. Furthermore, TNF-associated inflammation contributes to cachexia in patients with TB. This review focuses on the multifaceted role of TNF in the pathogenesis and prevention of TB and underscores the importance of investigating the functions of TNF and its receptors in the establishment of protective immunity against and in the pathology of TB. Such investigations will facilitate the development of therapeutic strategies that target TNF signaling, which makes beneficial and detrimental contributions to the pathogenesis of TB.
Keimyung Author(s)(Kor)
김진경
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2092-6685
Source
https://immunenetwork.org/DOIx.php?id=10.4110/in.2024.24.e4
DOI
10.4110/in.2024.24.e4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45323
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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