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Effectiveness and Tolerability of Combination Pharmacotherapy With Stimulant and Non-Stimulant in Children With Attention Deficit Hyperactivity Disorder

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Author(s)
Hyung Nam ParkNa Yeong KongHee-Cheol KimYang Tae KimSung-Won JungHojun Lee
Keimyung Author(s)
Kim, Hee ChulKim, Yang TaeJung, Sung WonLee, Ho Jun
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
J Korean Acad Child Adolesc Psychiatry
Issued Date
2024
Volume
35
Issue
1
Keyword
Attention deficit hyperactivity disorderCombinationMethylphenidateAtomoxetineChild.
Abstract
Objectives:
This study aimed to investigate the effectiveness and safety of combining psychostimulants and nonstimulants for patients under treatment for attention deficit hyperactivity disorder (ADHD).

Methods:
The study included 96 patients aged 6-12 years who were diagnosed with ADHD, among whom 34 received combination pharmacotherapy, 32 received methylphenidate monotherapy, and 30 received atomoxetine monotherapy. Statistical analysis was conducted to compare treatment and adverse effects among groups and to analyze changes before and after combination pharmacotherapy. The difference between combination pharmacotherapy and monotherapy was investigated. Logistic regression analysis was used to identify the predictors of combination pharmacotherapy.

Results:
No significant differences were observed between the groups in terms of age or pretreatment scores. The most common adverse effect experienced by 32% of patients in the combination pharmacotherapy group was decreased appetite. Clinical global impression- severity score decreased significantly after combination pharmacotherapy. All three groups showed significant clinical global impression- severity score improvements over time, with no significant differences among them. The predictive factors for combination pharmacotherapy included the Child Behavior Checklist total score internalizing subscale.

Conclusion:
Combination pharmacotherapy with methylphenidate and atomoxetine is a relatively effective and safe option for patients with ADHD who do not respond to monotherapy.
Keimyung Author(s)(Kor)
김희철
김양태
정성원
이호준
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2233-9183
Source
https://www.jkacap.org/journal/view.html?doi=10.5765/jkacap.230048
DOI
10.5765/jkacap.230048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45337
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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