계명대학교 의학도서관 Repository

Effect of preoperative pan-immune-inflammation value on clinical and oncologic outcomes after colorectal cancer surgery: a retrospective study

Metadata Downloads
Author(s)
Yun Ju SeoKyeong Eui KimWoon Kyung JeongSeong Kyu BaekSung Uk Bae
Keimyung Author(s)
Jeong, Woon KyungBaek, Seong KyuBae, Sung Uk
Department
Dept. of Surgery (외과학)
Journal Title
Ann Surg Treat Res
Issued Date
2024
Volume
106
Issue
3
Keyword
Colorectal neoplasmsInflammationImmune systemPostoperative complicationSurvival
Abstract
Purpose:
Surgical resection, the primary treatment for colorectal cancer (CRC), is often linked with postoperative complications that adversely affect the overall survival rates (OS). The pan-immune-inflammation value (PIV), a novel biomarker, is promising in evaluating cancer prognoses. We aimed to explore the impact of preoperative immune inflammation status on postoperative and long-term oncological outcomes in patients with CRC.

Methods:
A retrospective analysis of 203 patients with CRC who underwent surgery (January 2016–June 2020) was conducted. The preoperative PIV was calculated as [(neutrophil count + platelet count + monocyte count) / lymphocyte counts]. The PIV optimal cutoff value was determined based on the OS using the Contal and O’Quigley methods.

Results:
A PIV value ≥155.90 was defined as high. Patients were categorized into low-PIV (n = 85) and high-PIV (n = 118) groups. Perioperative clinical outcomes (total operation time, time to gas out, sips of water, soft diet, and hospital stay) were not significantly different between the groups. The high-PIV group exhibited more postoperative complications (P = 0.024), and larger tumor size compared with the low-PIV group. Multivariate analysis identified that American Society of Anesthesiologists grade III (P = 0.046) and high-PIV (P = 0.049) were significantly associated with postoperative complications. The low-PIV group demonstrated higher OS (P = 0.001) and disease-free survival rates (DFS) (P = 0.021) compared with the high-PIV group. Advanced N stage (P = 0.005) and high-PIV levels (P = 0.047) were the identified independent prognostic factors for OS, whereas advanced N stage (P = 0.045) was an independent prognostic factor for DFS.

Conclusion:
Elevated preoperative PIV was associated with an increased incidence of postoperative complications and served as an independent prognostic factor for OS.
Keimyung Author(s)(Kor)
정운경
백성규
배성욱
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2288-6796
Source
https://www.astr.or.kr/search.php?where=aview&id=10.4174/astr.2024.106.3.169&code=6037ASTR&vmode=FULL
DOI
10.4174/astr.2024.106.3.169
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45371
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.