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Surgical outcome and risk scoring to predict survival after hepatic resection for hepatocellular carcinoma with portal vein tumor thrombosis

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Author(s)
Tae-Seok KimKwangho YangGi Hong ChoiHye Yeon YangDong-Sik KimHye-Sung JoGyu-Seong ChoiKwan Woo KimYoung Chul YoonJaryung HanDoo Jin KimShin HwangKoo Jeong Kang
Keimyung Author(s)
Kim, Tae SeokKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Ann Hepatobiliary Pancreat Surg
Issued Date
2024
Volume
28
Issue
2
Keyword
Hepatocellular carcinomaTumor thrombosisPortal veinHepatectomyPrognosis
Abstract
Backgrounds/Aims:
The hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is classified as the advanced stage (BCLC stage C) with extremely poor prognosis, and in current guidelines is recommended for systemic therapy. This study aimed to evaluate the surgical outcomes and long-term prognosis after hepatic resection (HR) for patients who have HCC combined with PVTT.

Methods:
We retrospectively analyzed 332 patients who underwent HR for HCC with PVTT at ten tertiary referral hospitals in South Korea.

Results:
The median overall and recurrence-free survival after HR were 32.4 and 8.6 months, while the 1-, 3-, and 5-year overall survival rates were 75%, 48%, and 39%, respectively. In multivariate analysis, tumor number, tumor size, AFP, PIVKA−II, neutrophil-to-lymphocyte ratio, and albumin–bilirubin (ALBI) grade were significant prognostic factors. The risk scoring was developed using these seven factors–tumor, inflammation and hepatic function (TIF), to predict patient prognosis. The prognosis of the patients was well stratified according to the scores (log-rank test, p < 0.001).

Conclusions:
HR for patients who have HCC combined with PVTT provided favorable survival outcomes. The risk scoring was useful in predicting prognosis, and determining the appropriate treatment strategy for those patients who have HCC with PVTT.
Keimyung Author(s)(Kor)
김태석
강구정
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
2508-5859
Source
https://www.ahbps.org/journal/view.html?uid=2588
DOI
10.14701/ahbps.24-048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45388
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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