계명대학교 의학도서관 Repository

Clinical Benefit of Intravascular Imaging Compared With Conventional Angiography in Left Main Coronary Artery Intervention

Metadata Downloads
Author(s)
Woochan KwonJoo Myung LeeKyeong Ho YunKi Hong ChoiSeung-Jae LeeJong-Young LeeSang Yeub LeeSang Min KimJae Young ChoChan Joon KimHyo-Suk AhnChang-Wook NamHyuck-Jun YoonYong Hwan ParkWang Soo LeeJin-Ok JeongPil Sang SongJoon-Hyung DohSang-Ho JoChang-Hwan YoonMin Gyu KangJin-Sin KohKwan Yong LeeYoung-Hyo LimYun-Hyeong ChoJin-Man ChoWoo Jin JangKook-Jin ChunDavid HongTaek Kyu ParkJeong Hoon YangSeung-Hyuk ChoiHyeon-Cheol GwonJoo-Yong Hahn
Keimyung Author(s)
Nam, Chang WookYoon, Hyuck Jun
Department
Dept. of Internal Medicine (내과학)
Journal Title
Circ Cardiovasc Interv
Issued Date
2023
Volume
16
Issue
12
Keyword
angiographycoronary arterypatientspercutaneous coronary interventionprognosis
Abstract
Background:
The RENOVATE-COMPLEX-PCI (Randomized Controlled Trial of Intravascular Imaging Guidance Versus Angiography-Guidance on Clinical Outcomes After Complex Percutaneous Coronary Intervention) demonstrated that intravascular imaging-guided percutaneous coronary intervention (PCI) improved clinical outcome compared with angiography-guided PCI for patients with complex coronary artery lesions. This study aims to assess whether the prognostic benefit of intravascular imaging-guided procedural optimization persists in patients undergoing PCI for left main coronary artery disease.

Methods:
Of 1639 patients enrolled in the RENOVATE-COMPLEX-PCI, 192 patients with left main coronary artery disease were selected for the current prespecified substudy. Selected patients were randomly assigned to either the intravascular imaging-guided PCI group (n=138) or the angiography-guided PCI group (n=54). The primary end point was target vessel failure defined as a composite of cardiac death, target vessel-related myocardial infarction, or clinically driven target vessel revascularization.

Results:
At a median follow-up of 2.1 years (interquartile range 1.1 to 3.0 years), intravascular imaging-guided PCI was associated with lower incidence of primary end point compared with angiography-guided PCI (6.8% versus 25.1%; hazard ratio, 0.31 [95% CI, 0.13-0.76]; P=0.010). This significant reduction in primary end point was mainly driven by a lower risk of cardiac death or spontaneous target vessel-related myocardial infarction (1.6% versus 12.7%; hazard ratio, 0.16 [95% CI, 0.03-0.82]; P=0.028). Intravascular imaging-guided PCI was independently associated with a lower risk of primary end point, even after adjusting for various clinical factors (hazard ratio, 0.29 [95% CI, 0.12-0.72]; P=0.007).

Conclusions:
Intravascular imaging-guided PCI showed clinical benefit over angiography-guided PCI for left main coronary artery disease in reducing the risk of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization.

Registration:
URL: https://www.clinicaltrials.gov; Unique identifier: NCT03381872.
Keimyung Author(s)(Kor)
남창욱
윤혁준
Publisher
School of Medicine (의과대학)
Type
Article
ISSN
1941-7632
Source
https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013359
DOI
10.1161/CIRCINTERVENTIONS.123.013359
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/45460
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.